Hydralazine use while Breastfeeding
Drugs containing Hydralazine: Apresoline, BiDil, HydrALAZINE Plus, HHR, Serathide, Serpazide, Apresazide, Hydrap-ES, Unipres, Serpex, Show all 16 »Marpres, Ser-Ap-Es, Hydra-Zide, Diuretic Ap-Es, Uni Serp, Tri-Hydroserpine
Hydralazine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited milk level and infant data and a long history of use in postpartum mothers indicate that hydralazine is an acceptable antihypertensive in nursing mothers, even those nursing newborns.
Maternal Levels In one case report, a mother taking oral hydralazine 50 mg 3 times daily for at least 8 weeks postpartum had hydralazine milk levels of about 130 mcg/L at 0.5 and 2 hours after a dose. In addition, milk contained an amount of acid-labile hydrazones with undefined pharmacologic activity. The authors estimated that a breastfed infant would receive a maximum of 13 mcg per feeding at this maternal dosage.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
No adverse effects reported in one infant breastfed for 8 weeks.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
1. Liedholm H, Wahlin-Boll E, Hanson A et al. Transplacental passage and breast milk concentration of hydralazine. Eur J Clin Pharmacol. 1982;21:417-9. PMID: 7200428
CAS Registry Number
- Antihypertensive Agents
- Vasodilator Agents
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- Hydralazine use during Pregnancy
- Hydralazine Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy