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Active substance(s): TERBUTALINE SULPHATE

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Package leaflet: Information for the user

Bricanyl® Respules® 2.5 mg/ml Nebuliser Solution
terbutaline sulfate
Read all of this leaflet carefully before you start using
this medicine because it contains important information
for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or
• This medicine has been prescribed for you only. Do not
pass it on to others. It may harm them, even if their signs
of illness are the same as yours.
• If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects not
listed in this leaflet. See section 4.
What is in this leaflet
1. What Bricanyl Respules are and what they are used for
2. What you need to know before you use Bricanyl Respules
3. How to use Bricanyl Respules
4. Possible side effects
5. How to store Bricanyl Respules
6. Contents of the pack and other information
1. What Bricanyl Respules are and what they are
used for
Bricanyl Respules contain a medicine called terbutaline. This
belongs to a group of medicines called ‘beta-agonists’. These
work by relaxing certain muscles and opening up the airways
in the lungs.
• Bricanyl Respules are used for asthma and other
breathing problems where you have a tight chest and
difficulty breathing.
• Bricanyl should not be used alone for the regular
treatment of asthma or other breathing conditions. If you
are using Bricanyl every day then your doctor should
have also prescribed you another type of medication such
as an “inhaled corticosteroid”, which helps reduce the
swelling and inflammation in your lungs.
• A Respule is a small plastic container that contains a
liquid. The liquid is put into a machine called a nebuliser.
This machine turns the medicine into a fine mist which
you breathe in through a face mask or mouthpiece.
2. What you need to know before you use
Bricanyl Respules
Do not use Bricanyl Respules:
• If you are allergic to terbutaline or any of the other
ingredients of this medicine (listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before using
Bricanyl Respules if:
• You have diabetes. If so, you may need some extra blood
sugar tests when you start using Bricanyl Respules.
• You have a history of heart disease, irregular heart
rhythm or angina.
• You have an overactive thyroid gland.
If you are not sure if any of the above apply to you, talk to
your doctor or pharmacist before using Bricanyl Respules.
Other medicines and Bricanyl Respules
Tell your doctor or pharmacist if you are taking, have recently
taken or might take any other medicines. This includes
medicines that you buy without a prescription and herbal
medicines. Bricanyl Respules can affect the way that some
medicines work and some medicines can have an effect on
Bricanyl Respules.

In particular, tell your doctor or pharmacist if you are taking
any of the following medicines:
• Steroid medicines (such as prednisolone).
• Medicines called ‘xanthines’ (such as theophylline).
• Medicines called ‘beta-blockers’ (such as atenolol or
propranolol) including eye drops (such as timolol).
• Water tablets (diuretics) such as furosemide (also known
as frusemide).
If you are to undergo surgery with general anaesthetics it is
important that you inform your doctor about all medicine you
use, including Bricanyl to protect you from adverse effects
(e.g. irregular heart beat).
Pregnancy, breast-feeding and fertility
• If you are pregnant or breast-feeding, think you may be
pregnant or are planning to have a baby, ask your doctor
or pharmacist for advice before using this medicine.
• If you become pregnant while you are using
Bricanyl Respules, talk to your doctor straight away.
• If you are using Bricanyl Respules every day rather than
as needed, then Bricanyl Respules should be used with
caution at the end of pregnancy since it relaxes the womb.
Driving and using machines
Bricanyl Respules is not likely to affect you being able to
drive or use any tools or machines.
3. How to use Bricanyl Respules
Always use this medicine exactly as your doctor or pharmacist
has told you. Check with your doctor or pharmacist if you are
not sure.
The solution in a Respule must be put into a nebuliser and made
into a fine mist before it can be breathed in. It is then inhaled
through a face mask or mouthpiece. Instructions for using your
nebuliser are given after the section ‘How much to take’.
How much to take
The recommended dose is:
1 to 2 Respules, 2 to 4 times a day
• Adults:
• Children over 8 years: 1 Respule, 2 to 4 times a day
• Younger children are usually prescribed lower doses.
Instructions for using Bricanyl Respules
1. Break off a Respule from the strip. Leave the rest in the
foil envelope.
2. Hold upright. Twist off the top of the Respule to open.
3. Place the open end of the Respule firmly inside the
nebuliser cup. Squeeze slowly to put the liquid in the cup.
4. Throw the empty Respule away. Put the top back on the
nebuliser cup.
5. Connect the top of the cup to the face mask or mouthpiece.
6. Connect the bottom of the cup to the air pump. The air
pump should be connected to the compressor unit.
7. Turn on the nebuliser and breathe in the mist calmly and
deeply using the face mask or mouthpiece. If you are
using a face mask, make sure the face mask fits tightly.
8. You will know when your treatment is complete because the
fine mist will stop coming out of your mask or mouthpiece.
9. How long it takes to nebulise all the medicine depends on
the type of equipment you use. It will also depend on the
amount of medicine to be used.
10. After each use, you must wash the nebuliser cup and
mouthpiece (or face mask) in warm soapy water and
rinse well. After washing, dry these parts by turning on
the compressor and allowing air to blow through them.

Talk to your doctor straight away if:
• Your breathing is getting worse.
• You often wake at night with asthma.
• You start getting a tight chest.
• You are not getting relief from your current dose.
These are signs that your asthma is not being
controlled. You may need a different or additional
treatment straight away.
If you use more Bricanyl Respules than you should
If you use more Bricanyl Respules than you should, contact
your doctor or pharmacist.
If you forget to use Bricanyl Respules
• If you forget to have a dose, have it as soon as you
remember. However, if it is almost time for the next dose,
skip the missed dose.
• Do not take a double dose to make up for a forgotten dose.
If you stop using Bricanyl Respules
Do not stop taking your medicine without first discussing it
with your doctor.
If you have any further questions on the use of this medicine,
ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects,
although not everybody gets them.
Important side effects to look out for:
• Allergic reactions. The signs may include a swollen
face, skin rash, breathing problems, low blood pressure
(feeling faint) and collapse. It is not known how often
this happens. If this happens to you, stop using your
nebuliser and see a doctor straight away.
• Sudden wheezing soon after inhaling your dose
of Bricanyl Respules. It is not known how often
this happens. If this happens to you, stop using
Bricanyl Respules and see a doctor straight away.
Other possible side effects
Very Common (may affect more than 1 in 10 people)
• Trembling or shaking.
• Headache.
Common (may affect up to 1 in 10 people)
• Pounding or rapid heart beats (palpitations).
• Cramp or feeling tense.
• Low levels of potassium in your blood which may cause
muscle weakness, thirst, or ‘pins and needles’.
Not known (frequency cannot be estimated from
available data)
• Unusual or irregular heart beats.
• Chest pain (due to heart problems such as angina).
Tell your doctor if you develop this symptom whilst
receiving treatment with Bricanyl Respules, but do not
stop using this medicine unless told to.
• Feeling sick (nausea).
• Mouth and throat irritation.
• Changes in sleeping patterns and changes in behaviour,
such as feeling agitated, restless or hyperactive.
• Lactic acidosis is caused by a build-up of lactic acid in
your blood. Symptoms of lactic acidosis include recurrent
nausea and vomiting, abdominal pain and hyperventilation.
Do not be concerned by this list of side effects. You may not
get any of them.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist.
This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme. Website: By
reporting side effects you can help provide more information
on the safety of this medicine.
5. How to store Bricanyl Respules
• Keep this medicine out of the sight and reach of children.
• Once a foil envelope has been opened, the Respules inside
should be used within 3 months. Note: It is best to mark the
opening date on the foil envelope to help you remember.

Once you have opened a single Respule, any remaining
product cannot be regarded as sterile. This must be
considered if the intention is to use the remaining content
at a later occasion.
Each single Respule should be used within 24 hours
after it is opened. After this time the Respule and any
remaining contents should be thrown away.
Do not store above 30°C. Store Bricanyl Respules in their
original carton and foil, and out of direct sunlight.
Do not use this medicine after the expiry date which is
stated on the label and carton.
Do not throw away any medicines via wastewater or
household waste. Ask your pharmacist how to throw away
medicines you no longer use. These measures will help
protect the environment.

6. Contents of the pack and other information
What Bricanyl Respules contains
The active substance is terbutaline sulfate. Each
Bricanyl Respule contains 5 mg of the active ingredient,
terbutaline sulfate (equivalent to 2.5 mg/ml).
The other ingredients are sodium chloride, disodium edetate,
hydrochloric acid and water.
What Bricanyl Respules look like and the contents of
the pack
Respules are single dose plastic units containing
2 millilitres (ml) of solution.
The solution must be nebulised (made into a fine mist) before
it can be breathed in.
Bricanyl Respules are available in boxes of 20.
Marketing Authorisation Holder and Manufacturer
The Marketing Authorisation for Bricanyl Respules is held
by AstraZeneca UK Ltd, 600 Capability Green, Luton,
LU1 3LU, UK.
Bricanyl Respules are manufactured by AstraZeneca AB,
S-151 85, Södertälje, Sweden.

To listen to or request a copy of this
leaflet in Braille, large print or audio
please call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the
following information:
Product name
Bricanyl Respules 2.5 mg/ml
Nebuliser Solution
Reference number
This is a service provided by the
Royal National Institute of Blind
This leaflet was last revised in: March 2015
Bricanyl and Respules are trade marks of the AstraZeneca
group of companies.
© AstraZeneca 2015
RSP 14 0049a

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.