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Beta-lactamase inhibitors

What are Beta-lactamase inhibitors?

Beta-lactamase inhibitors are a class of medicine that block the activity of beta-lactamase enzymes (also called beta-lactamases), preventing the degradation of beta-lactam antibiotics. They tend to have little antibiotic activity on their own.

Beta-lactamase enzymes are produced by certain strains of the following bacteria: Bacteroides species, Enterococcus species, Hemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, and Staphylococcus species, either constitutively or on exposure to antimicrobials.

Beta-lactamases cleave the beta-lactam ring of susceptible penicillins and cephalosporins, inactivating the antibiotic. Some antimicrobials (eg, cefazolin and cloxacillin) are naturally resistant to certain beta-lactamases. The activity of the beta-lactams: amoxicillin, ampicillin, piperacillin, and ticarcillin, can be restored and widened by combining them with a beta-lactamase inhibitor.

Clavulanic acid, sulbactam, and tazobactam are all beta-lactamase inhibitors.

List of Beta-lactamase inhibitors:

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Drug NameView by: Brand | Generic Reviews Avg. Ratings
ampicillin / sulbactam systemic (Pro, More...)
2 reviews
piperacillin / tazobactam systemic (Pro, More...)
5 reviews
amoxicillin / clavulanate systemic (Pro, More...)
518 reviews
clavulanate / ticarcillin systemic (Pro, More...)
0 reviews