What are Beta-lactamase inhibitors?
Beta-lactamase inhibitors are a class of medicine that block the activity of beta-lactamase enzymes (also called beta-lactamases), preventing the degradation of beta-lactam antibiotics. They tend to have little antibiotic activity on their own.
Beta-lactamase enzymes are produced by certain strains of the following bacteria: Bacteroides species, Enterococcus species, Hemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, and Staphylococcus species, either constitutively or on exposure to antimicrobials.
Beta-lactamases cleave the beta-lactam ring of susceptible penicillins and cephalosporins, inactivating the antibiotic. Some antimicrobials (eg, cefazolin and cloxacillin) are naturally resistant to certain beta-lactamases. The activity of the beta-lactams: amoxicillin, ampicillin, piperacillin, and ticarcillin, can be restored and widened by combining them with a beta-lactamase inhibitor.
Clavulanic acid, sulbactam, and tazobactam are all beta-lactamase inhibitors.
List of Beta-lactamase inhibitors:
|Drug Name||View by: Brand | Generic||Reviews||Avg. Ratings|
|ampicillin / sulbactam systemic (Pro, More...)||2 reviews||8.5|
|piperacillin / tazobactam systemic (Pro, More...)||5 reviews||7.5|
|amoxicillin / clavulanate systemic (Pro, More...)||501 reviews||5.8|
|clavulanate / ticarcillin systemic (Pro, More...)||0 reviews||4.5|
Medical conditions associated with beta-lactamase inhibitors:
- Aspiration Pneumonia
- Bacterial Infection
- Bone infection
- Deep Neck Infection
- Febrile Neutropenia
- Intraabdominal Infection
- Joint Infection
- Kidney Infections
- Nosocomial Pneumonia
- Otitis Media
- Pelvic Inflammatory Disease
- Pneumonia with Cystic Fibrosis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Small Bowel Bacterial Overgrowth
- Strep Throat
- Surgical Prophylaxis
- Upper Respiratory Tract Infection
- Urinary Tract Infection