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Remdesivir use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on Apr 6, 2021.

Remdesivir Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the use of remdesivir during breastfeeding. Remdesivir is given intravenously because it is poorly absorbed orally, so infants are not likely to absorb clinically important amounts of the drug from milk. In addition, a newborn infants have received intravenous remdesivir therapy for Ebola with no serious adverse drug reactions.[1,2] Given this limited information, it does not appear that mothers receiving remdesivir need to avoid nursing, but until more data are available, remdesivir should be used with careful infant monitoring during breastfeeding.[3] The most common adverse effects reported after intravenous infusion include elevated aminotransferase and bilirubin levels and other liver enzyme elevations, diarrhea, rash, renal impairment and hypotension.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Dörnemann J, Burzio C, Ronsse A, et al. First newborn baby to receive experimental therapies survives Ebola virus disease. J Infect Dis. 2017;215:171–4. [PMC free article: PMC5583641] [PubMed: 28073857]
2.
Mulangu S, Dodd LE, Davey RT Jr, et al. A randomized, controlled trial of Ebola virus disease therapeutics. N Engl J Med. 2019;381:2293–303. [PubMed: 31774950]
3.
Aleissa MM, Silverman EA, Paredes Acosta LM, et al. New perspectives on antimicrobial agents: Remdesivir treatment for COVID-19. Antimicrob Agents Chemother. 2020;65:e01814–20. [PMC free article: PMC7927874] [PubMed: 33139290]

Substance Identification

Substance Name

Remdesivir

CAS Registry Number

1809249-37-3

Drug Class

Breast Feeding

Lactation

Antimetabolites

Antiviral Agents

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Further information

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