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Hepatitis B Vaccine use while Breastfeeding

Drugs containing Hepatitis B Vaccine: Vaxelis

Medically reviewed by Drugs.com. Last updated on April 10, 2021.

Hepatitis B Vaccine Levels and Effects while Breastfeeding

Summary of Use during Lactation

The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding infants and that breastfeeding is not a contraindication to the hepatitis B vaccine. Hepatitis B vaccine is recommended along with hepatitis B immune globulin to be given by injection to infants of mothers who are positive for hepatitis B surface antigen. No differences exist in infection rates between breast-fed and formula-fed infants born to hepatitis B-infected women, as long as the infant receives these preventative measures at birth.[1] Mothers with hepatitis B are encouraged to breastfeed their infants after their infants receive these preventative measures.[2,3] Breastfeeding also appears to reduce infant side effects associated with routine childhood immunization. Breastfed infants should be vaccinated according to the routine recommended schedules.[4-6]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Breastfeeding can enhance the response of the infant to certain vaccine antigens.[4,5,7] Breastfed infants are also less likely to have fever and may be less likely to experience anorexia and reduced energy intake after routine childhood immunization than those who are not breastfed.[8,9]

Breastfed infants of hepatitis B surface antigen positive mothers have a different response in the development of immunoglobulin subtypes after vaccination with hepatitis B vaccine than do formula-fed infants.[10] However, breastfeeding does not interfere with the infant's antibody response to hepatitis B vaccine.[11]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Xiao F, Lan A, Mo W. Breastfeeding from mothers carrying HBV would not increase the risk of HBV infection in infants after proper immunoprophylaxis. Minerva Pediatr. 2020;72:109–15. [PubMed: 28353321]
2.
Visvanathan K, Dusheiko G, Giles M, et al. Managing HBV in pregnancy. Prevention, prophylaxis, treatment and follow-up: Position paper produced by Australian, UK and New Zealand key opinion leaders. Gut. 2016;65:340–50. [PubMed: 26475631]
3.
Dionne-Odom J, Tita AT, Silverman NS. #38: Hepatitis B in pregnancy screening, treatment, and prevention of vertical transmission. Am J Obstet Gynecol. 2016;214:6–14. [PubMed: 26454123]
4.
Ezeanolue E, Harriman K, Hunter P, et al. Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). https://www​.cdc.gov/vaccines​/hcp/acip-recs​/general-recs/index.html Accessed June 5, 2020.
5.
Kimberlin DW, Brady MT, Jackson MA, et al. Red Book: 2018 Report of the Committee on Infectious Diseases. 31st ed. Elk Grove Village, IL: American Academy of Pediatrics. 2018.
6.
Gruslin A, Steben M, Halperin S, et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187–91. [PubMed: 19367691]
7.
Pabst HF. Immunomodulation by breast-feeding. Pediatr Infect Dis J. 1997;16:991–5. [PubMed: 9380478]
8.
Pisacane A, Continisio P, Palma O, et al. Breastfeeding and risk for fever after immunization. Pediatrics. 2010;125:e1448–52. [PubMed: 20478932]
9.
López-Alarcón M, Garza C, Habicht JP, et al. Breastfeeding attenuates reductions in energy intake induced by a mild immunologic stimulus represented by DPTH immunization: possible roles of interleukin-1beta, tumor necrosis factor-alpha and leptin. J Nutr. 2002;132:1293–8. [PubMed: 12042449]
10.
Azzari C, Resti M, Rossi ME, et al. Modulation by human milk of IgG subclass response to hepatitis B vaccine in infants. J Pediatr Gastroenterol Nutr. 1990;10:310–5. [PubMed: 2324890]
11.
Wang JS, Zhu QR, Wang XH. Breastfeeding does not pose any additional risk of immunoprophylaxis failure on infants of HBV carrier mothers. Int J Clin Pract. 2003;57:100–2. [PubMed: 12661791]

Substance Identification

Substance Name

Hepatitis B Vaccine

Drug Class

Breast Feeding

Lactation

Vaccines

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Further information

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