Zostavax Side Effects

Generic Name: zoster vaccine live

Note: This page contains side effects data for the generic drug zoster vaccine live. It is possible that some of the dosage forms included below may not apply to the brand name Zostavax.

It is possible that some side effects of Zostavax may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to zoster vaccine live: parenteral for injection for sub-q use

Side effects include:

Injection site reactions (erythema, pain/tenderness, swelling, pruritus, warmth, hematoma, induration), headache, extremity pain.

For Healthcare Professionals

Applies to zoster vaccine live: subcutaneous powder for injection


Cardiovascular side effects have included angina pectoris, coronary artery disease, coronary occlusion, cardiovascular disorder, myocardial ischemia, congestive heart failure, and myocardial infarction.


Local side effects have included injection site erythema, pain, tenderness, swelling, hematoma, pruritus, and warmth.

Nervous system

Nervous system side effects have included headache and asthenia.


Respiratory side effects have included pulmonary edema, respiratory infection, respiratory disorder, and asthma exacerbation.


Dermatologic side effects have included zoster-like and varicella-like rashes and skin disorders.


Gastrointestinal side effects have included diarrhea.


General side effects have included fever, flu syndrome, and rhinitis.

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