Zolinza Side Effects

Generic Name: vorinostat

Please note - some side effects for Zolinza may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Zolinza - for the Consumer

Zolinza

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zolinza:

Chills; constipation; cough; diarrhea; dizziness; dry mouth; fatigue; hair loss; headache; loss of appetite; muscle aches; nausea; taste changes; vomiting; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); black, tarry, or bloody stools; calf or leg pain, swelling, redness, or warmth to the touch; chest pain; coughing up blood; fainting; fast or irregular heartbeat; muscle pain or spasms; severe nausea, vomiting, or diarrhea; shortness of breath; swelling of the hands, ankles, or feet; symptoms of high blood sugar (eg, increased urination, thirst, or hunger; confusion; drowsiness; flushing; fast breathing; fruit-like breath odor); symptoms of infection (eg, fever; persistent or severe chills, cough, or sore throat); unusual bleeding or bruising; unusual sweating; unusual weakness or tiredness; vomit that looks like coffee grounds.

Zolinza Side Effects - for the Professional

Zolinza

• The most common adverse reactions (incidence ≥20%) are diarrhea, fatigue, nausea, thrombocytopenia, anorexia and dysgeusia. (6)

Side Effects by Body System

General

General side effects including fatigue (52.3%), decreased weight (20.9%), chills (16.3%), dizziness (15.1%), and pyrexia (10.5%) have been reported. A case of syncope has also been reported.

Gastrointestinal

Gastrointesinal side effects including diarrhea (52.3%), nausea (40.7%), dysgeusia (27.9%), anorexia (24.4%), dry mouth (16.3%), vomiting (15.1%), constipation (15.1%), and decreased appetite (14%) have been reported. Cases of cholecystitis and gastrointestinal hemorrhage have also been reported.

Hematologic

Hematologic side effects including thrombocytopenia (25.6%), increased blood creatinine (16.3%), and anemia (up to 14.0%) have been reported.

Musculoskeletal

Musculoskeletal side effects including muscle spasms (19.8%) have been reported. A case of spinal cord injury has also been reported.

Dermatologic

Dermatologic side effects including alopecia (18.6%) and pruritis (11.6%) have been reported. A case of exfoliative dermatitis has also been reported.

Cardiovascular

Cardiovascular side effects including peripheral edema (12.8%) have been reported. Cases of deep vein thrombosis, myocardial infarction, and ischemic stroke have also been reported.

Nervous system

Nervous system side effects including headache (11.6%) have been reported.

Respiratory

Respiratory side effects including upper respiratory infection (10.5%), cough (10.5%), and pulmonary embolism (4.7%) have been reported. A case of lobar pneumonia has also been reported.

Oncologic

Oncologic side effects including squamous cell carcinoma (3.5%) have been reported. A case of T-cell lymphoma has also been reported.

Other

Other side effects have been reported including a case of a death from unknown causes. Cases of enterococcal infection, infection, sepsis, and streptococcal bacteremia have also been reported.

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