Vorinostat Pregnancy and Breastfeeding Warnings
Vorinostat is also known as: Zolinza
Vorinostat Pregnancy Warnings
Vorinostat has been assigned to pregnancy category D by the FDA. Animal studies have revealed that vorinostat crosses the placenta and is found in fetal plasma at levels up to 50% of maternal concentrations. Treatment-related developmental effects including decreased mean live fetal weights, incomplete ossifications of the skull, thoracic vertebra, sternebra, and skeletal variations (cervical ribs, supernumerary ribs, vertebral count, and sacral arch variations), reductions in mean live fetal weight, an elevated incidence of incomplete ossification of the metacarpals, and a dose-related increase in the incidence of malformations of the gall bladder have been reported in animal studies. There are no controlled data in human pregnancy. Vorinostat should only be given during pregnancy when there are no alternatives and benefit outweighs risk.
Vorinostat Breastfeeding Warnings
There are no data on the excretion of vorinostat into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from vorinostat, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
- vorinostat Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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