Xifaxan Side Effects
Generic name: rifaximin
Note: This document contains side effect information about rifaximin. Some of the dosage forms listed on this page may not apply to the brand name Xifaxan.
Some side effects of Xifaxan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to rifaximin: oral tablet
Along with its needed effects, rifaximin (the active ingredient contained in Xifaxan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rifaximin:More common
- Black, tarry stools
- dizziness or lightheadedness
- muscle spasm
- rapid breathing
- shortness of breath
- trouble sleeping
- unable to sleep
- Blood in urine
- bloody nose
- chest pain
- continuing ringing or buzzing or other unexplained noise in the ears
- feeling of constant movement of self or surroundings
- increased heart rate
- sensation of spinning
- sunken eyes
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- Cracks in the skin
- hives or welts
- itching skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of heat from the body
- red, swollen skin scaly skin
- redness of skin
Some side effects of rifaximin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- difficulty in moving
- excess air or gas in the stomach or intestines
- frequent urge to defecate
- full feeling
- lower back or side pain
- muscle pain or stiffness
- pain in joints
- passing gas
- stomach pain
- straining while passing stool
- swelling of the hands, ankles, feet, or lower legs
- Abnormal dreams
- blurred vision
- decreased urination
- difficulty having a bowel movement (stool)
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry lips
- dry mouth
- ear pain
- feeling of warmth
- hearing loss
- loss of appetite
- loss of taste
- painful or difficult urination
- pale skin
- redness of the face, neck, arms and occasionally, upper chest
- sore throat
- swollen glands
- wrinkled skin
For Healthcare Professionals
Applies to rifaximin: oral tablet
Gastrointestinal side effects have included nausea (up to 14%), flatulence (11%), abdominal pain (up to 9%), abdominal distension (up to 8%), rectal tenesmus (7%), upper abdominal pain (6%), defecation urgency (6%), constipation (up to 6%), stomach discomfort (less than 5%), and vomiting (2%). Lower abdominal pain, abdominal tenderness, dry mouth, and esophageal variceal bleed have been reported in greater than 2% but less than 5% of patients. Diarrhea, blood in stool, dry throat, dysentery, fecal abnormality, gingival disorder, inguinal hernia, and dry lips have been reported in less than 2% of patients. Straining and bad taste in mouth have also been reported. Clostridium difficile associated colitis has been reported during postmarketing experience.
Other side effects have included peripheral edema (15%), fatigue (up to 12%), ascites (11%), back pain (6%), pyrexia (up to 6%), chest pain (less than 5%), and pain (less than 5%). Generalized edema, influenza-like illness, contusion, fall, and procedural pain have been reported in greater than 2% but less than 5% of patients. Ear pain, motion sickness, malaise, and hot flashes have been reported in less than 2% of patients.
Nervous system side effects have included dizziness (up to 13%) and headache (10%). Vertigo, amnesia, disturbance in attention, hypoesthesia, memory impairment, and tremor have been reported in greater than 2% but less than 5% of patients. Migraine, syncope, tinnitus, and loss of taste have been reported in less than 2% of patients.
Hypersensitivity side effects have included exfoliative dermatitis, rash, angioneurotic edema (swelling of face and tongue and difficulty swallowing), urticaria, pruritus, flushing, and anaphylaxis during postmarketing experience and have occurred as early as within 15 minutes of rifaximin (the active ingredient contained in Xifaxan) administration.
Dermatologic side effects have included pruritus (up to 9%), rash (up to 5%), and cellulitis (greater than 2% but less than 5%). Clamminess, sunburn, and increased sweating have been reported in less than 2% of patients.
Musculoskeletal side effects have included muscle spasms (up to 9%), arthralgia (up to 6%), myalgia (less than 5%), and pain in extremity (greater than 2% but less than 5%). Neck pain and weakness have been reported in less than 2% of patients.
Hematologic side effects have included anemia (8%). Lymphocytosis, monocytosis, and neutropenia have been reported in less than 2% of patients.
Respiratory side effects have included cough (7%), nasopharyngitis (up to 7%), dyspnea (up to 6%), upper respiratory tract infection (less than 5%), and rhinitis (less than 5%). Pneumonia and epistaxis have been reported in greater than 2% but less than 5% of patients. Respiratory tract infection, nasal passage irritation, pharyngitis, pharyngolaryngeal pain, and rhinorrhea have been reported in less than 2% of patients.
Psychiatric side effects have included depression (7%), insomnia (up to 7%), confusional state (greater than 2% but less than 5%), and abnormal dreams (less than 2%).
Metabolic side effects have included increased weight (greater than 2% but less than 5%), anorexia (less than 5%), and dehydration (less than 5%). Hyperglycemia, hyperkalemia, hypoglycemia, and hyponatremia have been reported in greater than 2% but less than 5% of patients. Decreased weight has been reported in less than 2% of patients.
Genitourinary side effects have included choluria, dysuria, hematuria, polyuria, proteinuria, urinary frequency, and blood in urine in less than 2% of patients.
Cardiovascular side effects have included hypotension (greater than 2% but less than 5%).
Hepatic side effects have included increased aspartate aminotransferase in less than 2% of patients.
More Xifaxan resources
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