Xiaflex Side Effects

Generic name: collagenase clostridium histolyticum

Note: This document contains side effect information about collagenase clostridium histolyticum. Some of the dosage forms listed on this page may not apply to the brand name Xiaflex.

Some side effects of Xiaflex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to collagenase clostridium histolyticum: injectable powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking collagenase clostridium histolyticum (the active ingredient contained in Xiaflex) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver at once if you have a serious side effect such as:

• feeling like you might pass out (even while lying down);

• bruising or bleeding in the treated hand;

• severe pain, itching, redness, warmth, swelling, or other irritation in the treated hand;

• numbness or tingling in the treated hand;

• fever, chills, body aches, flu symptoms, swollen glands;

• swollen glands in your elbow or underarm; or

• sudden pain, snapping or popping sound, bruising, loss of movement, or swelling in the joints of your hand.

Less serious side effects of collagenase clostridium histolyticum may include:

• mild pain or tenderness in the treated hand;

• cracked skin; or

• underarm pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to collagenase clostridium histolyticum: injectable powder for injection

Musculoskeletal

Musculospiral side effects have included tendon ruptures and other serious injury to the injected extremity,

Local

Local side effects have included swelling of the injected hand, contusion, injection site reaction and bleeding, and pain in the treated extremity.

Cardiovascular

Cardiovascular side effects have included vasovagal syncope after finger extension procedures.

Other

Other side effects have included lymphadenopathy, lymph node pain, and axillary pain.

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