Vincristine liposome Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 26, 2023.

Applies to vincristine liposome: intravenous suspension.

Serious side effects

Along with its needed effects, vincristine liposome may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:

More common

• Black, tarry stools
• bleeding gums
• blood in the urine or stools
• blurred vision
• burning, tingling, numbness or pain in the hands, arms, feet, or legs
• chest pain or tightness
• chills
• confusion
• cough
• diarrhea
• dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
• fever
• lack or loss of strength
• lower back or side pain
• nausea
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• rapid breathing
• severe constipation
• severe vomiting
• sneezing
• sore throat
• stomach pain
• sweating
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unsteadiness or awkwardness
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common

• Blue lips, fingernails, or skin
• bone pain
• change in muscle reflexes
• coughing up blood
• dark urine
• headache
• irregular, fast or slow, or shallow breathing
• joint pain, stiffness, or swelling
• light-colored stools
• muscle pain or weakness
• stomach pain, continuing
• swelling of the feet or lower legs
• vomiting
• weakness of the muscles in your face
• yellow eyes or skin

Other side effects

Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Anxiety
• mental depression
• nightmares or unusually vivid dreams

Incidence not known

• Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit.

Cardiovascular

Common (1% to 10%): Hypotension, cardiac arrest, vascular disorder^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (52%), diarrhea (37%), decreased appetite (33%)

Common (1% to 10%): Constipation, abdominal pain, ileus/colonic pseudo-obstruction^[Ref]

General

Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death^[Ref]

Hematologic

Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)

Frequency not reported: Neutropenia, thrombocytopenia^[Ref]

Metabolic

Frequency not reported: Increased aspartate aminotransferase, tumor lysis syndrome^[Ref]

Musculoskeletal

Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain^[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)

Common (1% to 10%): Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia, asthenia^[Ref]

Other

Very common (10% or more): Pyrexia (15%), fatigue (12%)^[Ref]

Psychiatric

Frequency not reported: Mental status changes^[Ref]

Respiratory

Common (1% to 10%): Respiratory distress, respiratory failure, pneumonia^[Ref]

Immunologic

Common (1% to 10%): Septic shock, staphylococcal bacteremia^[Ref]

Local

Frequency not reported: Extravasation tissue injury^[Ref]

Hepatic

Frequency not reported: Hepatic toxicity^[Ref]

Oncologic

Very common (10% or more): Pyrexia (43%), fatigue (41%)

Frequency not reported: Pain, septic shock, staphylococcal bacteremia^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer