Vilazodone Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 25, 2023.

Applies to vilazodone: oral tablet.

Serious side effects of Vilazodone

Along with its needed effects, vilazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vilazodone:

Less common

• Actions that are out of control
• anxiety
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain or discomfort
• decreased interest in sexual intercourse
• delayed or inability to have an orgasm
• extra heartbeat
• fast, irregular, pounding, or racing heartbeat or pulse
• inability to have or keep an erection
• irritability
• loss in sexual ability, desire, drive, or performance
• shakiness in the legs, arms, hands, or feet
• sweating
• talking, feeling, and acting with excitement
• trembling or shaking of the hands or feet

Other side effects of Vilazodone

Some side effects of vilazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea
• dizziness
• dry mouth
• nausea
• trouble sleeping

Less common

• Abnormal dreams
• aching or discomfort in the lower legs or sensation of crawling in the legs
• acid or sour stomach
• belching
• blindness
• bloated or full feeling
• blurred vision
• change in taste
• decreased vision
• difficulty with moving
• drowsiness
• dry eyes
• excess air or gas in the stomach or intestines
• feeling jittery
• headache, severe and throbbing
• heartburn
• increased or decreased appetite
• increased sweating
• indigestion
• loss of appetite
• loss of taste
• muscle pain or stiffness
• night sweats
• pain in the joints
• passing gas
• relaxed and calm
• restlessness
• sleepiness or unusual drowsiness
• stomach pain, discomfort, or upset
• unusual tiredness or weakness
• vomiting
• weakness

Incidence not known

• Decrease in smell
• eye pain
• loss of sense of smell

For Healthcare Professionals

Applies to vilazodone: oral kit, oral tablet.

General

The most commonly observed side effects were: diarrhea, nausea, headache, and dry mouth.^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 29%), nausea (up to 24%)

Common (1% to 10%): Abdominal distension, abdominal pain, pain, dry mouth, dyspepsia, flatulence, gastroenteritis, vomiting

Frequency not reported: Abdominal discomfort, acute pancreatitis, upper abdominal pain^[Ref]

Nervous system

Very common (10% or more): Headache (up to 15%)

Common (1% to 10%): Dizziness, paresthesia, sedation, somnolence, tremor

Uncommon (0.1% to 1%): Migraine, serotonin syndrome

Frequency not reported: Akathisia, paresthesia/electric shock sensation, restless legs syndrome, sensory disturbances

Postmarketing reports: Sleep paralysis^[Ref]

Psychiatric

Common (1% to 10%): Abnormal dreams, abnormal orgasm, decreased libido, insomnia, restlessness

Uncommon (0.1% to 1%): Activation of mania/hypomania, panic attack

Frequency not reported: Agitation, anorgasmia, anxiety, clinical worsening, confusion, discontinuation symptoms, dysphoric mood, emotional lability, lethargy, seizures, suicide risk

Postmarketing reports: Irritability, hallucinations, suicide attempt, suicidal ideation^[Ref]

Metabolic

Common (1% to 10%): Increased appetite, increased weight

Frequency not reported: Hyponatremia^[Ref]

Genitourinary

Common (1% to 10%): Ejaculation disorder, erectile dysfunction^[Ref]

Cardiovascular

Common (1% to 10%): Palpitations

Uncommon (0.1% to 1%): Ventricular extrasystoles^[Ref]

Other

Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Tinnitus^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia^[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision, dry eye

Rare (0.01% to 0.1%): Cataracts^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Hyperhidrosis, night sweats

Postmarketing reports: Drug eruption, generalized rash, rash, urticaria^[Ref]

Hematologic

Frequency not reported: Abnormal Bleeding^[Ref]

Frequently asked questions

• What are some common side effects of antidepressants?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer