Vilazodone Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Initial dose: 10 mg orally once a day for 7 days, followed by 20 mg orally once a day for an additional 7 days
Maintenance dose: 40 mg orally once a day

Comments: This drug should be taken with food.

Use: Major Depressive Disorder (MDD)

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Concomitant use with CYP450 3A4 inhibitors: Dose should be reduced to 20 mg if co-administered with a strong inhibitor of CYP450 3A4 (e.g., ketoconazole). During co-administration with moderate inhibitors of CYP450 3A4 (e.g., erythromycin), dose should be reduced to 20 mg for patients with intolerable side effects. The dose should be readjusted to the original level when CYP450 3A4 inhibitors are discontinued.

Concomitant use with CYP450 3A4 inducers: Dose may be increased up to 2-fold when concomitantly used with strong CYP450 3A4 inducers (e.g., carbamazepine) for more than 14 days. The maximum daily dose should not exceed 80 mg. If CYP450 3A4 inducers are discontinued, dose should be reduced to the original level in 14 days.

Precautions

BOXED WARNING(S):
-Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants.
-Monitor for worsening and emergence of suicidal thoughts and behaviors.
-Vilazodone is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Patients should be reassessed periodically to determine the need for maintenance treatment and the appropriate dose for treatment.

Patient advice:
-Patients and their caregivers should be advised about the benefits and risks associated with treatment with vilazodone and should be counseled in its appropriate use.
-Patients should avoid alcohol while taking this drug.
-Patients should be advised to notify their healthcare provider if they develop an allergic reaction such as rash, hives, swelling, or difficulty breathing.
-Patients should use caution about operating hazardous machinery, including automobiles, until they are reasonably certain that vilazodone does not adversely affect their ability to engage in such activities.

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