Trifluoperazine Side Effects
For the Consumer
Applies to trifluoperazine: oral tablets
Side effects include:
Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia), drowsiness, fatigue, muscular weakness, insomnia, blurred vision, skin reactions or rash, anorexia, dry mouth, hypotension, amenorrhea, galactorrhea.
For Healthcare Professionals
Applies to trifluoperazine: compounding powder, intramuscular solution, oral concentrate, oral tablet
Nervous system side effects including motor restlessness, jitteriness, spasm of the neck muscles, rigidity of back muscles, opisthotonos, carpopedal spasm, hyperreflexia, dystonia, akathisia, dyskinesia, grand mal and petit mal seizures, trismus, protrusion of the tongue, drooling, tremors, shuffling gait, and chewing movements have been frequently reported.[Ref]
Cardiovascular side effects including tachycardia, cardiac arrest, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, EKG changes, and syncope have been reported.[Ref]
Hematologic side effects including agranulocytosis, thrombocytopenia, pancytopenia, eosinophilia, hemolytic anemia, aplastic anemia, and leukopenia have rarely been reported.[Ref]
Hepatic side effects including hepatocellular injury, jaundice, biliary stasis, and hepatitis have rarely been reported.[Ref]
Respiratory side effects including dyspnea, laryngeal edema, and asthma have been infrequently reported.[Ref]
Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, false-positive pregnancy tests, menstrual irregularity, ejaculatory disorders, and impotence have been reported.[Ref]
Gastrointestinal side effects including nausea, vomiting, obstipation, and constipation have been reported.[Ref]
Dermatologic side effects including dermatitis, photosensitivity, itching, erythema, urticaria, eczema, exfoliative dermatitis, edema, pruritus, rash, alopecia, skin pigmentation, epithelial keratopathy, and seborrhea have been reported.[Ref]
Endocrine side effects including hyperglycemia, hypoglycemia, and glycosuria have been reported.[Ref]
Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.[Ref]
General side effects including dry mouth, weight gain, increased appetite, headache, and hyperpyrexia have been reported.[Ref]
Psychiatric side effects including reactivation of psychotic processes and catatonic-like states have been infrequently reported.[Ref]
Musculoskeletal side effects including a case of laryngeal dystonia have been reported.[Ref]
1. "Product Information. Stelazine (trifluoperazine)" SmithKline Beecham, Philadelphia, PA.
2. Vogler CM, Szonyli G "Laryngeal dystonia secondary to neuroleptic medications." Med J Aust 175 (2001): 444-5
It is possible that some side effects of trifluoperazine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about trifluoperazine
- Other brands: Stelazine
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