Trifluoperazine Side Effects

Please note - some side effects for Trifluoperazine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Trifluoperazine - for the Consumer

Trifluoperazine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trifluoperazine:

Agitation; constipation; dizziness; drowsiness; dry mouth; enlarged pupils; headache; jitteriness; loss of appetite; nausea; stuffy nose; tiredness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); chest pain; confusion; decreased coordination; drooling; fainting; fast, slow, or irregular heartbeat; mask-like face; muscle spasms of the face, neck, or back; muscle weakness; new or worsening mental or mood problems; numbness of an arm or leg; prolonged or painful erection; restlessness; seizures; severe or persistent constipation; severe or persistent dizziness, drowsiness, or headache; shuffling walk; sleeplessness; stiff or rigid muscles; sudden shortness of breath or vomiting; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite); tremor; trouble urinating; twisting or twitching movements; uncontrolled muscle movements (eg, twitching of the face or tongue; loss of balance; uncontrolled movements of arms or legs; trouble speaking, breathing, or swallowing); unusual bruising or bleeding; unusual eye movements or inability to move eyes; unusual or excessive sweating; unusual tiredness or weakness; unusually pale skin; vision changes (eg, blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Nervous system

Nervous system side effects including motor restlessness, jitteriness, spasm of the neck muscles, rigidity of back muscles, opisthotonos, carpopedal spasm, hyperreflexia, dystonia, akathisia, dyskinesia, grand mal and petit mal seizures, trismus, protrusion of the tongue, drooling, tremors, shuffling gait, and chewing movements have been frequently reported.

Cardiovascular

Cardiovascular side effects including tachycardia, cardiac arrest, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, EKG changes, and syncope have been reported.

Hematologic

Hematologic side effects including agranulocytosis, thrombocytopenia, pancytopenia, eosinophilia, hemolytic anemia, aplastic anemia, and leukopenia have rarely been reported.

Hepatic

Hepatic side effects including hepatocellular injury, jaundice, biliary stasis, and hepatitis have rarely been reported.

Respiratory

Respiratory side effects including dyspnea, laryngeal edema, and asthma have been infrequently reported.

Genitourinary

Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, false-positive pregnancy tests, menstrual irregularity, ejaculatory disorders, and impotence have been reported.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, obstipation, and constipation have been reported.

Dermatologic

Dermatologic side effects including dermatitis, photosensitivity, itching, erythema, urticaria, eczema, exfoliative dermatitis, edema, pruritus, rash, alopecia, skin pigmentation, epithelial keratopathy, and seborrhea have been reported.

Endocrine

Endocrine side effects including hyperglycemia, hypoglycemia, and glycosuria have been reported.

Ocular

Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.

General

General side effects including dry mouth, weight gain, increased appetite, headache, and hyperpyrexia have been reported.

Psychiatric

Psychiatric side effects including reactivation of psychotic processes and catatonic-like states have been infrequently reported.

Musculoskeletal

Musculoskeletal side effects including a case of laryngeal dystonia have been reported.

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