Trifluoperazine Pregnancy and Breast Feeding Warnings

Trifluoperazine is also known as: Stelazine

Trifluoperazine Pregnancy Warnings

Trifluoperazine has not been formally assigned to a pregnancy category by the FDA. Trifluoperazine has been assigned to pregnancy Risk Factor C by Briggs et al. Animal studies have revealed evidence of fetotoxicity. There are no controlled data in human pregnancy. Trifluoperazine is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Adverse effects including prolonged jaundice, extrapyramidal signs, hyperreflexia, and hyporeflexia have been reported in newborn infants whose mothers received phenothiazines. Chromosomal aberrations in spermatocytes and abnormal sperm have been demonstrated in rodents treated with certain neuroleptics.

Trifluoperazine Lactation Warnings

There are no data on the excretion of trifluoperazine into human milk. However, there is evidence that phenothiazines in general are excreted into human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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