Trientine Side Effects

Brand Names: Syprine

Please note - some side effects for Trientine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Trientine - for the Consumer

Trientine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trientine:

Abnormal muscle contractions or spasms; iron deficiency; lupus; muscle weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; red, swollen, or blistered skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Nervous system

Central nervous system side effects have included dystonia, malaise, myasthenia gravis, and weakness.

Immunologic

Immunologic side effects have included systemic lupus erythematosus.

Hematologic

Hematologic side effects have included iron deficiency and hypochromic microytic anemia. The hypochromic microytic anemia was reported in 4 patients being treated with trientine who had primary biliary cirrhosis.

Musculoskeletal

Musculoskeletal system side effects have included muscle spasm, muscle pain, cramps, and rhabdomyolysis. The rhabdomyolysis was reported in 4 patients being treated with trientine who had primary biliary cirrhosis.

Gastrointestinal

Gastrointestinal side effects have included heartburn, epigastric pain and tenderness, acute gastritis, aphthoid ulcers, abdominal pain, melena, and anorexia. These side effects were reported in 4 patients being treated with trientine who had primary biliary cirrhosis.

Dermatologic

Dermatologic side effects have included thickening, fissuring, and flaking of the skin. These side effects were reported in 4 patients being treated with trientine who had primary biliary cirrhosis.

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