Trientine Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Wilson's Disease

Initial dose: 750 to 1250 mg orally per day, on an empty stomach, in 2 to 4 equally divided doses.

Maximum dose: 2000 mg orally per day.

Usual Pediatric Dose for Wilson's Disease

Initial dose (age 12 or under): 500 to 750 mg orally, on an empty stomach, in 2 to 4 equally divided doses.

Maximum dose (age 12 or under): 1500 mg orally per day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The daily dose of trientine should be increased only when the clinical response is not adequate or the concentration of free serum copper is persistently above 20 mcg/dL. Optimal long-term maintenance dosage should be determined at 6 to 12 month intervals.

Precautions

Trientine is contraindicated in patients with gelatin, iron oxide, stearic acid or titanium allergies.

There have been reports of asthma, bronchitis, and dermatitis occurring after prolonged environmental exposure in workers who use trientine as a hardener of epoxy resins. Patients should be monitored for signs of possible hypersensitivity.

Controlled studies of the safety and effectiveness of trientine in pediatric patients have not been conducted. It has been used clinically in pediatric patients as young as 6 years with no reported adverse experiences.

Dialysis

Data not available

Other Comments

Trientine should be given on an empty stomach, at least 1 hour before or 2 hours after meals and at least 1 hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed.

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