Trientine use while Breastfeeding
Drugs containing Trientine: Syprine
Trientine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited information indicates that trientine is not detectable in breastmilk. The effect of trientine on breastmilk copper and zinc concentrations in milk is conflicting, but breastfed infants appear to have normal serum copper and zinc plasma levels. Based on available data, it appears that trientine is acceptable to use during breastfeeding.
Maternal Levels. Four patients received trientine for Wilson's disease in dosages of 1000, 1500 (2 patients) and 1750 mg daily. Trientine was not detectable by HPLC in the breastmilk of any of the mothers' milk samples.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Three infants were breastfed during maternal treatment of Wilson's disease with trientine. Serum zinc and copper concentrations were normal in these infants.
Possible Effects on Lactation
Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with trientine. One abstract reported that breastmilk concentrations were normal during therapy, but another abstract from the same authors reported lower milk concentrations of zinc and copper.
Alternate Drugs to Consider
1. Izumi Y. [Can mothers with Wilson's disease give her breast milk to their infant?]. Teikyo Med J. 2012;35:17-24.
2. Kaga F, Kodama H, Shiga K et al. Copper and zinc status in the breast milk of mothers with Wilson disease. J Inherit Metab Dis. 2008;31 (Suppl. 1):157. Abstract. DOI: doi:10.1007/s10545-008-9975-0
3. Shiga K, Kaga H, Kodama H et al. Copper and zinc concentrations in the breast milk of mothers with Wilson disease and effects on infants. J Inherit Metab Dis. 2006;29 Suppl. 1:139. Abstract. DOI: doi:10.1007/s10545-006-9995-6
CAS Registry Number
LactMed Record Number
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.