Trientine use while Breastfeeding
Drugs containing Trientine: Syprine
Trientine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited information indicates that trientine may be preferable to penicillamine in the treatment of Wilson's disease in nursing mothers because it does not lower the concentrations of copper or zinc in the milk or in the serum of their infants.
Drug Levels
Maternal Levels. Copper bound to trientine is detectable in the breastmilk of mothers taking trientine for Wilson's disease. However, amounts were not reported.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Three infants were breastfed during maternal treatment of Wilson's disease with trientine. Serum zinc and copper concentrations were normal in these infants.[2]
Possible Effects on Lactation
Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with trientine. One abstract reported that breastmilk concentrations were normal during therapy,[2] but another abstract from the same authors reported lower milk concentrations of zinc and copper.[1]
References
1. Kaga F, Kodama H, Siga K et al. Copper and zinc status in the breast milk of mothers with Wilson disease. J Inherit Metab Dis. 2008;31 (Suppl. 1):157. Abstract.
2. Shiga K, Kaga H, Kodama H et al. Copper and zinc concentrations in the breast milk of mothers with Wilson disease and effects on infants. J Inherit Metab Dis. 2006;29 Suppl. 1:139. Abstract.
Trientine Identification
Substance Name
CAS Registry Number
112-24-3
Drug Class
Administrative Information
LactMed Record Number
561
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-07-09
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Trientine use during Pregnancy
- Trientine Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
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