Trientine use while Breastfeeding

Drugs containing Trientine: Syprine

Trientine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that trientine is not detectable in breastmilk. The effect of trientine on breastmilk copper and zinc concentrations in milk is conflicting,[1][2][3] but breastfed infants appear to have normal serum copper and zinc plasma levels. Based on available data, it appears that trientine is acceptable to use during breastfeeding.

Drug Levels

Maternal Levels. Four patients received trientine for Wilson's disease in dosages of 1000, 1500 (2 patients) and 1750 mg daily. Trientine was not detectable by HPLC in the breastmilk of any of the mothers' milk samples.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Three infants were breastfed during maternal treatment of Wilson's disease with trientine. Serum zinc and copper concentrations were normal in these infants.[3]

Possible Effects on Lactation

Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with trientine. One abstract reported that breastmilk concentrations were normal during therapy,[2] but another abstract from the same authors reported lower milk concentrations of zinc and copper.[1]

Alternate Drugs to Consider

Penicillamine

References

1. Izumi Y. [Can mothers with Wilson's disease give her breast milk to their infant?]. Teikyo Med J. 2012;35:17-24.

2. Kaga F, Kodama H, Shiga K et al. Copper and zinc status in the breast milk of mothers with Wilson disease. J Inherit Metab Dis. 2008;31 (Suppl. 1):157. Abstract. DOI: doi:10.1007/s10545-008-9975-0

3. Shiga K, Kaga H, Kodama H et al. Copper and zinc concentrations in the breast milk of mothers with Wilson disease and effects on infants. J Inherit Metab Dis. 2006;29 Suppl. 1:139. Abstract. DOI: doi:10.1007/s10545-006-9995-6

Trientine Identification

Substance Name

Trientine

CAS Registry Number

112-24-3

Drug Class

Administrative Information

LactMed Record Number

561

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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