Tranxene Side Effects

Generic Name: clorazepate

Note: This page contains side effects data for the generic drug clorazepate. It is possible that some of the dosage forms included below may not apply to the brand name Tranxene.

It is possible that some side effects of Tranxene may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

As well as its needed effects, clorazepate (the active ingredient contained in Tranxene) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking clorazepate, check with your doctor immediately:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking clorazepate, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Some clorazepate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • sleeplessness
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet

Nervous system

Nervous system side effects have been common and including drowsiness, dizziness, nervousness, fatigue, confusion, and headache. Less common nervous system effects have included insomnia, irritability, delirium, diplopia, depression, tremor, and slurred speech. A case of a rage reaction has been associated with clorazepate (the active ingredient contained in Tranxene) therapy.[Ref]

Other

Other side effects have included withdrawal symptoms after abrupt cessation of clorazepate (the active ingredient contained in Tranxene) These have included agitation, restlessness, nervousness, anxiety, insomnia, convulsions, tremor, nausea, headache and sweating.[Ref]

Respiratory

Respiratory side effects including respiratory depression is theoretically possible and has been reported during therapy with other benzodiazepines.[Ref]

Hepatic

Hepatic side effects have included a case of jaundice followed by focal hepatocellular necrosis.[Ref]

Dermatologic

Dermatologic side effects including a case of photo-onycholysis has been reported in association with clorazepate (the active ingredient contained in Tranxene) therapy. Another case of skin blistering in association with an overdose of amitriptyline and clorazepate has also been reported.[Ref]

References

1. Karch FE "Rage reaction associated with clorazepate dipotassium." Ann Intern Med 91 (1979): 61-2

2. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

3. Allgulander C, Borg S "Case report: a delirious abstinence syndrome associated with clorazepate (Tranxilen)." Br J Addict Alcohol Other Drugs 73 (1978): 175-7

4. Rickels K, Schweizer E, Csanalosi I, Case WG, Chung H "Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone." Arch Gen Psychiatry 45 (1988): 444-50

5. Cohen S, Khan A "Respiratory distress with use of lorazepam in mania." J Clin Psychopharmacol 7 (1987): 199-200

6. Parker JL "Potassium clorazepate (Tranxene)-induced jaundice." Postgrad Med J 55 (1979): 908-10

7. Torras H, Manuel Mascaro J, Jr Mascaro JM "Photo-onycholysis caused by clorazepate dipotassium." J Am Acad Dermatol 21 (1989): 1304-5

8. Herschthal D, Robinson MJ "Blisters of the skin in coma induced by amitriptyline and clorazepate dipotassium. Report of a case with underlying sweat gland necrosis." Arch Dermatol 115 (1979): 499

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