Tobradex Side Effects

Please note - some side effects for Tobradex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Tobradex - for the Consumer

TobraDex Drops

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using TobraDex Drops:

Burning or stinging when you first put the medicine in your eye.

Seek medical attention right away if any of these SEVERE side effects occur when using TobraDex Drops:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; itching or swelling of the eyelid; new or worsening eye pain, redness, swelling, or irritation; vision loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

TobraDex ST Drops

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using TobraDex ST Drops:

Burning or stinging when you first put the medicine in your eye.

Seek medical attention right away if any of these SEVERE side effects occur when using TobraDex ST Drops:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; itching or swelling of the eyelid; new or worsening eye pain, redness, swelling, or irritation; vision loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

TobraDex Ointment

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using TobraDex Ointment:

Burning or stinging when you first put the medicine in your eye; delayed wound healing.

Seek medical attention right away if any of these SEVERE side effects occur when using TobraDex Ointment:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; itching and swelling of the eyelid; redness or swelling of the eye; second infection; severe eye pain; vision loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

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Tobradex Side Effects - for the Professional

TobraDex

Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available. The most frequent adverse reactions to topical ocular tobramycin [TOBREX® (tobramycin ophthalmic solution)] are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than 4% of patients. Similar reactions may occur with the topical use of other aminoglycoside antibiotics. Other adverse reactions have not been reported; however, if topical ocular tobramycin is administered concomitantly with systemic aminoglycoside antibiotics, care should be taken to monitor the total serum concentration. The reactions due to the steroid component are: elevation of intraocular pressure (IOP) with possible development of glaucoma, and infrequent optic nerve damage; posterior subcapsular cataract formation; and delayed wound healing.

Secondary Infection. The development of secondary infection has occurred after use of combinations containing steroids and antimicrobials. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids. The possibility of fungal invasion must be considered in any persistent corneal ulceration where steroid treatment has been used. Secondary bacterial ocular infection following suppression of host responses also occurs.

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Side Effects by Body System - for Healthcare Professionals

Hypersensitivity

Hypersensitivity reactions have been reported with dexamethasone-tobramycin.

Ocular

Ocular side effects have included lid itching, swelling, and conjunctival hyperemia in < 4% of patients. The dexamethasone component has been associated with elevation of intraocular pressure with possible development of glaucoma, delayed wound healing, posterior subcapsular cataract formation, and optic nerve damage.

Corticosteroid containing preparations have also been reported to cause acute anterior uveitis, perforation of the globe, keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation, and ptosis.

Other

The development of a secondary infection has been reported in patients treated with antimicrobial and corticosteroid combinations. Fungal and viral infections of the cornea can develop with long-term application of corticosteroids.

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