Tegaserod Side Effects
It is possible that some side effects of tegaserod may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to tegaserod: oral tablet
As well as its needed effects, tegaserod may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking tegaserod, check with your doctor immediately:More common
- stomach pain
- feeling of warmth
- itching skin
- redness of the face, neck, arms and occasionally, upper chest
- swelling or puffiness of face
- Black, tarry stools
- bloody diarrhea
- bloody stools
- new or worsening abdominal pain
- rectal bleeding
- severe stomach pain with nausea and vomiting
If any of the following symptoms of overdose occur while taking tegaserod, get emergency help immediately:Symptoms of overdose
- Bloated, full feeling
- cold sweats
- dizziness, faintness, or lightheadedness when getting up from lying or sitting position
- excess air or gas in stomach or intestines
- passing gas
Some tegaserod side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common or rare
- Back pain
- disease or abnormality of the joint
- headache, severe and throbbing
- leg pain
For Healthcare Professionals
Applies to tegaserod: oral tablet
Cardiovascular side effects have included hypotension, angina pectoris, syncope, arrhythmia, bundle branch block, supraventricular tachycardia, and flushing. A case of myocardial infarction has been reported.
Myocardial infarction has been reported in a 64-year-old male after receiving two doses of tegaserod 6 mg.
Nervous system side effects have included headache, dizziness, migraine, insomnia, vertigo, and Raynaud's phenomenon.
Gastrointestinal side effects have included abdominal pain, diarrhea, nausea, flatulence, abdominal distention and pain, vomiting, dyspepsia, gastritis, gastroesophageal reflux, hemorrhoids, and proctalgia. Irritable colon, fecal incontinence, tenesmus, increased appetite, eructation, appendicitis, bilirubinemia, subileus, sphincter of Oddi spasm, bile duct stone, ischemic colitis, mesenteric ischemia, gangrenous bowel, rectal bleeding, and increases in abdominal surgeries, primarily cholecystectomies, have also been reported; however, causality was not clearly established.
Hepatic side effects have included increased SGOT and SGPT. Hepatitis, elevation in ALT, AST, and bilirubin have been reported during postmarketing experience.
Metabolic side effects have included increase in appetite, hypokalemia and hypovolemia secondary to diarrhea, and increased creatine phosphokinase.
Musculoskeletal side effects have included back pain, arthropathy, and myalgia. Other effects, regardless of causality, have included cramps.
Oncologic side effects have included breast carcinoma.
Psychiatric side effects have included attempted suicide, impaired concentration, emotional lability, increased appetite, sleep disorder and depression.
Respiratory side effects have included asthma.
Dermatologic side effects have included pruritus. Alopecia has been reported during postmarketing experience.
Endocrine side effects have included increased sweating.
Genitourinary side effects have included frequent micturition, polyuria, urinary tract infection, ovarian cyst, miscarriage, dysmenorrhea, and menorrhagia.
Renal side effects have included renal pain and albuminuria.
Side effects affecting the body as a whole have included accidental trauma (3% vs. 2% for placebo) and leg pain (1% vs. less than 1% for placebo). Other effects, regardless of causality, have included pain and facial edema.
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