Generic Name: linaclotide (LIN a KLOE tide)
Brand Names: Linzess

What is Linzess?

Linzess (linaclotide) works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements.

Linzess is used to treat chronic constipation, or chronic irritable bowel syndrome (IBS) in people who have had constipation as the main symptom.

Linzess may also be used for purposes not listed in this medication guide.

Important information

You should not use Linzess if you are allergic to linaclotide, or if you have a blockage in your stomach or intestines.

Do not give this medication to any child or teenager without the advice of a doctor.

Slideshow: 2013 Drug News Round-Up: Top 20 Stories

Take Linzess in the morning on an empty stomach, at least 30 minutes before your first meal. Do not crush, chew, break, or open a Linzess capsule. Swallow it whole.

Stop using Linzess and call your doctor at once if you have severe or ongoing diarrhea, severe stomach pain, or black, bloody, or tarry stools.

Before taking this medicine

You should not use Linzess if you are allergic to linaclotide, or if you have a blockage in your stomach or intestines.

FDA pregnancy category C. It is not known whether Linzess will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether linaclotide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Linzess should not be given to a child younger than 6 years old. Do not give this medication to any child or teenager without the advice of a doctor.

How should I take Linzess?

Take Linzess exactly as prescribed by your doctor. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, break, or open a Linzess capsule. Swallow it whole.

Take Linzess in the morning on an empty stomach, at least 30 minutes before your first meal.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed. Call your doctor if your symptoms do not improve, or if they get worse while using Linzess.

Store at room temperature away from moisture and heat.

Keep the capsules in their original container, along with the packet of moisture-absorbing preservative that comes with this medicine. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Linzess side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Linzess: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Linzess and call your doctor at once if you have a serious side effect such as:

  • severe or ongoing diarrhea;

  • severe stomach pain; or

  • black, bloody, or tarry stools.

Other common Linzess side effects may include:

  • mild diarrhea;

  • mild stomach discomfort;

  • heartburn, vomiting, gas, bloating;

  • headache; or

  • cold symptoms such as stuffy nose, sneezing, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Linzess?

Other drugs may interact with Linzess, including prescription, over-the-counter, vitamin, and herbal products. Tell your doctor about all medications you use, and those you start or stop using during your treatment with Linzess.

Where can I get more information?

  • Your pharmacist can provide more information about Linzess.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Linzess only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2012-11-14, 12:57:03 PM.

Hide
(web1)