Linzess Side Effects

Generic Name: linaclotide

Note: This page contains information about the side effects of linaclotide. Some of the dosage forms included on this document may not apply to the brand name Linzess.

Not all side effects for Linzess may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to linaclotide: oral capsule

In addition to its needed effects, some unwanted effects may be caused by linaclotide (the active ingredient contained in Linzess). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking linaclotide:

More common
  • Abdominal or stomach pain
  • severe diarrhea
Less common
  • Heartburn
  • loss of appetite
  • nausea
  • vomiting
  • weakness
Rare
  • Bleeding from the rectum
  • bloody, black, or tarry stools
  • confusion
  • cough
  • decreased urination
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • hives or welts
  • increase in heart rate
  • itching
  • lightheadedness
  • loss of bowel control
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • redness of the skin
  • shortness of breath
  • skin rash
  • sunken eyes
  • thirst
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
  • wrinkled skin

Some of the side effects that can occur with linaclotide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • chills
  • difficulty in breathing
  • ear congestion
  • excess air or gas in the stomach or intestines
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • passing gas
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Acid or sour stomach
  • belching
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to linaclotide: oral capsule

Gastrointestinal

Very common (10% or more): Diarrhea (up to 20%)
Common (1% to 10%): Abdominal pain, flatulence, abdominal distension, viral gastroenteritis, gastroesophageal reflux disease, vomiting, fecal incontinence, dyspepsia
Uncommon (0.1% to 1%): Defecation urgency

Cardiovascular

Uncommon (0.1% to 1%): Orthostatic hypotension

Dermatologic

Uncommon (0.1% to 1%): Urticaria
Frequency not reported: Rash

General

The most commonly reported reasons for treatment discontinuation were diarrhea and abdominal pain.

Genitourinary

Uncommon (0.1% to 1%): Hematochezia, melena, rectal hemorrhage

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reactions

Metabolic

Uncommon (0.1% to 1%): Dehydration, hypokalemia, decreased appetite
Rare (less than 0.1%): Decreased blood bicarbonate

Nervous system

Common (1% to 10%): Headache, dizziness

Other

Common (1% to 10%): Fatigue

Respiratory

Common (1% to 10%): Upper respiratory tract infection, sinusitis

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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