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Linzess Side Effects

Generic Name: linaclotide

Note: This page contains side effects data for the generic drug linaclotide. It is possible that some of the dosage forms included below may not apply to the brand name Linzess.

It is possible that some side effects of Linzess may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to linaclotide: oral capsule

As well as its needed effects, linaclotide (the active ingredient contained in Linzess) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking linaclotide, check with your doctor immediately:

More common
  • Abdominal or stomach pain
  • severe diarrhea
Less common
  • Heartburn
  • loss of appetite
  • nausea
  • vomiting
  • weakness
Rare
  • Bleeding from the rectum
  • bloody, black, or tarry stools
  • confusion
  • cough
  • decreased urination
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • hives or welts
  • increase in heart rate
  • itching
  • lightheadedness
  • loss of bowel control
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • redness of the skin
  • shortness of breath
  • skin rash
  • sunken eyes
  • thirst
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
  • wrinkled skin

Some linaclotide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Body aches or pain
  • chills
  • difficulty in breathing
  • ear congestion
  • excess air or gas in the stomach or intestines
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • passing gas
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Acid or sour stomach
  • belching
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to linaclotide: oral capsule

Gastrointestinal

Very common (10% or more): Diarrhea (16 to 20%)
Common (1% to 10%): Upper and/or lower abdominal pain (7%), flatulence (4 to 6%), abdominal distension (2 to 3%), severe diarrhea (2%), gastroesophageal reflux disease (1 to 2%), dyspepsia (1 to less than 2%), fecal incontinence (1 to less than 2%)
Uncommon (0.1% to 1%): In patients with IBS-C, less than 1% reported hematochezia and none reported melena

Immunologic

Common (1% to 10%): Viral gastroenteritis (1 to 3%)

Nervous system

Common (1% to 10%): Headache (4%), fatigue (1 to 2%)

Respiratory

Common (1% to 10%): Upper respiratory tract infection (5%), sinusitis (3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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