Linzess Side Effects

Generic Name: linaclotide

Note: This page contains side effects data for the generic drug linaclotide. It is possible that some of the dosage forms included below may not apply to the brand name Linzess.

It is possible that some side effects of Linzess may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to linaclotide: oral capsule

Along with its needed effects, linaclotide (the active ingredient contained in Linzess) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking linaclotide:

More common
  • Abdominal or stomach pain
  • severe diarrhea
Less common
  • Heartburn
  • loss of appetite
  • nausea
  • vomiting
  • weakness
  • Bleeding from the rectum
  • bloody, black, or tarry stools
  • confusion
  • cough
  • decreased urination
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • hives or welts
  • increase in heart rate
  • itching
  • lightheadedness
  • loss of bowel control
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • redness of the skin
  • shortness of breath
  • skin rash
  • sunken eyes
  • thirst
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing
  • wrinkled skin

Some side effects of linaclotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • chills
  • difficulty in breathing
  • ear congestion
  • excess air or gas in the stomach or intestines
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • passing gas
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common
  • Acid or sour stomach
  • belching
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to linaclotide: oral capsule


Very common (10% or more): Diarrhea (16 to 20%)
Common (1% to 10%): Upper and/or lower abdominal pain (7%), flatulence (4 to 6%), abdominal distension (2 to 3%), severe diarrhea (2%), gastroesophageal reflux disease (1 to 2%), dyspepsia (1 to less than 2%), fecal incontinence (1 to less than 2%)
Uncommon (0.1% to 1%): In patients with IBS-C, less than 1% reported hematochezia and none reported melena


Common (1% to 10%): Viral gastroenteritis (1 to 3%)

Nervous system

Common (1% to 10%): Headache (4%), fatigue (1 to 2%)


Common (1% to 10%): Upper respiratory tract infection (5%), sinusitis (3%)

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