Stendra Side Effects

Generic Name: avanafil

Note: This document contains side effect information about avanafil. Some of the dosage forms listed on this page may not apply to the brand name Stendra.

Some side effects of Stendra may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to avanafil: oral tablet

Along with its needed effects, avanafil (the active ingredient contained in Stendra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avanafil:

Less common
  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • Arm, back, or jaw pain
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chest pain or discomfort
  • chest tightness or heaviness
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • increased erection
  • lower back or side pain
  • nausea and vomiting
  • pain in the groin or genitals
  • pain, redness, or swelling in the arm or leg
  • rapid weight gain
  • sharp back pain just below the ribs
  • shortness of breath
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of avanafil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Feeling of warmth
  • fever
  • muscle aches
  • redness of the face, neck, arms, and occasionally, upper chest
  • sore throat
  • stuffy or runny nose
Less common
  • Acid or sour stomach
  • belching
  • body aches or pain
  • change in color vision
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty moving
  • ear congestion
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • loss of voice
  • muscle pain or stiffness
  • pain or tenderness around the eyes and cheekbones
  • rash
  • shivering
  • sneezing
  • sweating
  • trouble sleeping
  • Anxiety
  • bloody nose
  • bone pain
  • burning feeling in the chest or stomach
  • confusion
  • cool, pale skin
  • depression
  • feeling of constant movement of self or surroundings
  • increased hunger
  • itching skin
  • muscle aching or cramping
  • muscle spasms
  • nightmares
  • seizures
  • sensation of spinning
  • shakiness
  • sleepiness or unusual drowsiness
  • sleeplessness
  • slurred speech
  • swollen joints
  • tenderness in the stomach area
  • unable to sleep

For Healthcare Professionals

Applies to avanafil: oral tablet


Cardiovascular side effects have included flushing (up to 10.1%), abnormal electrocardiogram (up to 3.0%), hypertension (less than 2%), angina (less than 1%), unstable angina (less than 1%), deep vein thrombosis (less than 1%), and palpitations (less than 1%).


Dermatologic side effects have included rash (less than 2%), and pruritus (less than 1%).


Gastrointestinal side effects have included dyspepsia (less than 2%), nausea (less than 2%), constipation (less than 2%), diarrhea (less than 2%), gastritis (less than 1%), gastroesophageal reflux disease (less than 1%), hypoglycemia (less than 1%), oropharyngeal pain (less than 1%), stomach discomfort (less than 1%), and vomiting (less than 1%).


General side effects have included peripheral edema (less than 1%), and fatigue (less than 1%).


Genitourinary side effects have included balanitis (less than 1%), increased erection (less than 1%), hematuria (less than 1%), pollakiuria (less than 1%), and urinary tract infection (less than 1%).


Laboratory abnormalities have included increased blood glucose (less than 1%), increased alanine aminotransferase (less than 1%).


Musculoskeletal side effects have included back pain (up to 3.2%), arthralgia (less than 2%), muscle spasms (less than 1%), musculoskeletal pain (less than 1%), myalgia (less than 1%), and pain in extremity (less than 1%).

Nervous system

Nervous system side effects have included headache (up to 12.1%), dizziness (up to 2.0%), insomnia (less than 1%), somnolence (less than 1%), and vertigo (less than 1%).


Psychiatric side effects have included depression (less than 1%).


Renal side effects have included nephrolithiasis (less than 1%).


Respiratory side effects have included nasopharyngitis (up to 5.1%), nasal congestion (up to 3.0%), upper respiratory infection (less than 2%), bronchitis (less than 2%), influenza (less than 2%), sinusitis (less than 2%), sinus congestion (less than 2%), cough (less than 1%), exertional dyspnea (less than 1%), epistaxis (less than 1%), and wheezing (less than 1%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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