Sodium thiosulfate Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 6, 2023.

Applies to sodium thiosulfate: intravenous solution.

Serious side effects of Sodium thiosulfate

Along with its needed effects, sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium thiosulfate:

More common

• Black, tarry stools
• bone pain
• chills
• cough or hoarseness
• decreased urine
• dizziness
• dry mouth
• fast heartbeat
• fever
• high blood pressure
• increased thirst
• irritability
• loss of appetite
• lower back or side pain
• mood changes
• muscle pain, cramps, or twitching
• nausea
• numbness or tingling in the hands, feet, or lips
• painful or difficult urination
• pale skin
• seizures
• sore throat
• swelling of the feet or lower legs
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting

Incidence not known

• Blurred vision
• chest tightness
• confusion
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• headache
• hives, itching, or skin rash
• muscle tremors
• nervousness
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• restlessness
• slow or fast heartbeat
• stomach cramps
• sweating

Get emergency help immediately if any of the following symptoms of overdose occur while taking sodium thiosulfate:

Symptoms of overdose

• Agitation
• blurred vision
• mental changes
• muscle cramps
• nausea and vomiting
• pain in the joints
• ringing in the ears
• seeing, hearing, or feeling things that are not there

Other side effects of Sodium thiosulfate

Some side effects of sodium thiosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Swelling or inflammation of the mouth

For Healthcare Professionals

Applies to sodium thiosulfate: compounding powder, intravenous solution.

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea, osmotic disturbances^[Ref]

Nervous system

Frequency not reported: Headache, disorientation, salty taste in mouth, warm sensation over body^[Ref]

Cardiovascular

Frequency not reported: Hypotension^[Ref]

Psychiatric

Frequency not reported: Psychotic behavior including agitation, delusions, and hallucinations^[Ref]

Musculoskeletal

Frequency not reported: Arthralgia, hyperreflexia, muscle cramps^[Ref]

Hematologic

Frequency not reported: Prolonged bleeding time^[Ref]

Other

Frequency not reported: Tinnitus^[Ref]

Ocular

Frequency not reported: Blurred vision^[Ref]

Genitourinary

Frequency not reported: Diuretic effects^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer