Cyanokit

Generic Name: hydroxocobalamin (injection) (hye DROX o koe BAL a min)
Brand Names: Cyanokit, Hydroxocobalamin

What is Cyanokit?

Cyanokit contains hydroxocobalamin, a form of vitamin B-12. It is used as an antidote to cyanide poisoning. Hydroxocobalamin works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

Cyanokit is used in an emergency to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin.

Cyanokit may also be used for purposes not listed in this medication guide.

Important information

If possible before you receive Cyanokit, tell your caregivers if you have high blood pressure, heart disease, congestive heart failure, liver disease, or kidney disease (or if you are on dialysis).

Also tell your caregivers if you have ever had a severe allergic reaction to hydroxocobalamin, Vitamin B12, or cyanocobalamin (Nascobal, Cobolin, Cyomin, and others).

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In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received Cyanokit.

Cyanokit can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received a Cyanokit injection. You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with this medicine. This rash should go away without treatment. Call your doctor if you have a rash that lasts longer than 4 weeks. If your skin turns red after receiving this medication, avoid exposure to sunlight or tanning beds. Cyanokit can make you sunburn more easily while your skin is still red. Wear protective clothing and use sunscreen (SPF 30 or higher) until your skin color returns to normal.

Before receiving Cyanokit

If possible before you receive Cyanokit, tell your caregivers if you have:

  • high blood pressure;

  • heart disease;

  • congestive heart failure;

  • liver disease;

  • kidney disease (or if you are on dialysis); or

  • if you have ever had a severe allergic reaction to hydroxocobalamin, Vitamin B12, or cyanocobalamin (Nascobal, Cobolin, Cyomin, and others).

FDA pregnancy category C. Tell your doctor if you are pregnant. It is not known whether Cyanokit will harm an unborn baby. However, the benefits of treating cyanide poisoning may outweigh any risks posed by Cyanokit, for both you and your baby. It is not known whether hydroxocobalamin passes into breast milk or if it could harm a nursing baby. You should not breast-feed after you have been treated with Cyanokit. In an emergency situation, it may not be possible before you are treated with this medicine to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Cyanokit?

Cyanokit is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Cyanokit must be given slowly, and the IV infusion can take at least 15 minutes to complete.

Cyanokit is usually given only once. However, you may receive a second dose if needed.

Your breathing, blood pressure, oxygen levels, heart function, and other vital signs will be watched closely while you are receiving Cyanokit.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received a Cyanokit injection.

What happens if I miss a dose?

Since Cyanokit is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.

What happens if I overdose?

Since Cyanokit is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid?

If your skin turns red after receiving this medication, avoid exposure to sunlight or tanning beds. Cyanokit can make you sunburn more easily while your skin is still red. Wear protective clothing and use sunscreen (SPF 30 or higher) until your skin color returns to normal.

Cyanokit side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Cyanokit: hives; chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat. You may develop an acne-like skin rash within 1 to 4 weeks after you are treated with Cyanokit. This rash should go away without treatment. Call your doctor if you have a rash that lasts longer than 4 weeks. Call your doctor at once if you have a serious side effect such as:

  • bright red blood in your stools;

  • chest pain, fast or uneven heart rate;

  • severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus;

  • swelling in your feet or ankles;

  • a light-headed feeling, like you might pass out; or

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common Cyanokit side effects may include:

  • nausea;

  • headache;

  • acne, skin rash or redness;

  • red coloring of your urine (may last 2 to 5 weeks); or

  • pain, swelling, or irritation of your skin where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Cyanokit?

There may be other drugs that can interact with Cyanokit. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Cyanokit.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cyanokit only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 3.03. Revision Date: 2014-02-13, 4:36:23 PM.

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