Samsca Side Effects

Generic Name: tolvaptan

Note: This document contains side effect information about tolvaptan. Some of the dosage forms listed on this page may not apply to the brand name Samsca.

Some side effects of Samsca may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to tolvaptan: oral tablet

Along with its needed effects, tolvaptan (the active ingredient contained in Samsca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolvaptan:

More common
  • Abdominal or stomach pain
  • blurred vision
  • dry mouth
  • flushed, dry skin
  • frequent urination
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • increased volume of pale, dilute urine
  • nausea
  • sweating
  • thirst
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
Less common
  • Abdominal or stomach tenderness
  • anxiety
  • blood in the urine
  • bloody stools
  • blue lips, fingernails, or skin
  • bruising
  • chest pain
  • confusion
  • cough
  • coughing or vomiting blood
  • dark-colored urine
  • dizziness or lightheadedness
  • fainting
  • fast, slow, irregular or shallow heartbeat
  • fever
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • muscle cramps or spasms
  • muscle pain or stiffness
  • pain, redness, or swelling in the arm or leg
  • persistent bleeding or oozing from puncture sites, mouth, or nose
  • pink or red urine
  • rash
  • rectal bleeding
  • shortness of breath
  • sudden shortness of breath or troubled breathing
  • sweating
  • vaginal bleeding

Some side effects of tolvaptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • lack or loss of strength
Less common
  • Loss of appetite
  • weight loss

For Healthcare Professionals

Applies to tolvaptan: oral tablet

Cardiovascular

Cardiovascular side effects have included deep vein thrombosis, intracardiac thrombus, deep vein thrombosis, and ventricular fibrillation.

Endocrine

Endocrine side effects have included diabetic ketoacidosis, hyperglycemia, and anorexia.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, nausea, ischemic colitis, gastrointestinal bleeding, and constipation.

General

General side effects have included thirst, asthenia, and pyrexia.

Genitourinary

Genitourinary side effects have included urethral hemorrhage and vaginal hemorrhage.

Hematologic

Hematologic side effects have included prolonged prothrombin time and disseminated intravascular coagulation.

Musculoskeletal

Musculoskeletal side effects have included rhabdomyolysis.

Nervous system

Nervous system side effects have included cerebrovascular accidents. Postmarketing reports have included osmotic demyelination syndrome.

Renal

Renal side effects have included pollakiuria and polyuria.

Respiratory

Respiratory side effects have included pulmonary embolism and respiratory failure.

Metabolic

Metabolic side effects have included postmarketing reports of hypernatremia.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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