Vaprisol

Generic Name: conivaptan (koe NYE vap tan)
Brand Names: Vaprisol

What is Vaprisol?

Vaprisol (conivaptan) reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.

Vaprisol is used to treat hyponatremia (low sodium levels). Vaprisol improves urine flow without causing the body to lose too much sodium as you urinate.

Vaprisol may also be used for purposes other than those listed in this medication guide.

Important information

You should not receive Vaprisol if you are allergic to conivaptan or corn products, or if you are unable to urinate.

Before you receive Vaprisol, tell your doctor if you have congestive heart failure, liver disease, kidney disease, alcoholism, or if you are malnourished.

To be sure Vaprisol is helping your condition, your blood will need to be tested often. Tell your caregivers at once if you have a serious side effect such as confusion, extreme thirst, muscle weakness or limp feeling, trouble speaking or swallowing, mood changes, or swelling or discomfort where the IV needle is placed. There are many other drugs that should not be used together with Vaprisol, including certain antibiotics or antifungal medicines, heart or blood pressure medication, and HIV/AIDS medicine.

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Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Before receiving Vaprisol

You should not receive Vaprisol if you are allergic to conivaptan or corn products, or if you are unable to urinate. You should not use Vaprisol if you are using any of the following drugs:

  • imatinib (Gleevec);

  • isoniazid (for treating tuberculosis);

  • an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

  • an antidepressant such as nefazodone;

  • antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

  • heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or

  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra).

To make sure you can safely receive Vaprisol, tell your doctor if you have any of these other conditions:

  • congestive heart failure;

  • liver disease;

  • kidney disease;

  • alcoholism; or

  • if you are malnourished.

FDA pregnancy category C. It is not known whether Vaprisol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Vaprisol. It is not known whether conivaptan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving Vaprisol.

See also: Pregnancy and breastfeeding warnings (in more detail)

How is Vaprisol given?

Vaprisol is injected into a vein through an IV. You will receive this injection in a hospital setting. Vaprisol is given through an IV line and a needle placed into one of your large veins (such as in your upper chest).

Vaprisol is infused around-the-clock for up to 4 days. This medication is usually given only in a hospital.

Because Vaprisol can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.

To be sure Vaprisol is helping your condition, your blood will need to be tested often.

What happens if I miss a dose?

Since Vaprisol is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid?

Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Vaprisol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Vaprisol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

  • feeling like you might pass out;

  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);

  • trouble speaking, trouble swallowing, weakness, mood changes, muscle spasm or weakness in your arms and legs, seizure;

  • pain, redness, or swelling where the IV needle is placed;

  • swelling, rapid weight gain; or

  • pain or burning when you urinate.

Less serious Vaprisol side effects may include:

  • mild fever;

  • headache;

  • diarrhea; or

  • vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Vaprisol?

Many drugs can interact with Vaprisol. Below is just a partial list. Tell your doctor if you are using:

  • digoxin (Lanoxin);

  • an antibiotic such as doxycycline (Doryx, Oracea, Periostat, Vibramycin), rifampin (Rifater, Rifadin, Rifamate), rifabutin (Mycobutin), tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap), or trimethoprim (Proloprim, Bactrim, Septra, SMX-TMP);

  • anti-malaria medication;

  • an antidepressant;

  • anti-psychotic medication;

  • asthma or allergy medication such as albuterol (Proventil, Ventolin), budesonide (Pulmicort, Rhinocort), fluticasone (Flonase, Flovent), montelukast (Singulair), theophylline (Elixophyllin, Theo-24, Uniphyl);

  • a beta-blocker such as bisoprolol (Zebeta, Ziac);

  • cancer medicine such as bortezomib (Velcade), busulfan, docetaxel (Taxotere), doxorubicin (Adriamycin), exemestane (Aromasin), etoposide (VePesid, Toposar), flutamide (Eulexin), ifosfamide (Ifex), irinotecan (Camptosar), letrozole (Femara), paclitaxel (Taxol), tamoxifen (Soltamox), teniposide (Vumon), vinorelbine (Navelbine), vincristine (Oncovin, Vincasar), vinblastine (Velban);

  • cholesterol-lowering drugs such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);

  • diabetes medication such as nateglinide (Starlix), pioglitazone (Actos), repaglinide (Prandin);

  • erectile dysfunction medicine;

  • ergot medicines such as D.H.E. 45, Ergomar, Cafergot, Ergotrate, Methergine, Migergot, or Migranal;

  • heart or blood pressure medications such as amiodarone (Cordarone, Pacerone), amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), disopyramide (Norpace), enalapril (Vasotec), isradipine (Dynacirc), losartan (Cozaar, Hyzaar), nicardipine (Cardene), nimodipine (Nimotop), nisoldipine (Sular), quinidine (Quin-G);

  • HIV medicines such as efavirenz (Sustiva), nevirapine (Viramune), or tipranavir (Aptivus);

  • HIV medicines such as efavirenz (Sustiva, Atripla), nevirapine (Viramune), or tipranavir (Aptivus);

  • narcotic medications;

  • a sedative such as clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), and others;

  • seizure medication; or

  • stomach acid reducers such as lansoprazole (Prevacid), ondansetron (Zofran), rabeprazole (AcipHex).

This list is not complete and there are many other drugs that can interact with Vaprisol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Vaprisol.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 2.03. Revision Date: 2011-11-10, 3:21:24 PM.

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