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Renagel Side Effects

Generic Name: sevelamer

Note: This page contains side effects data for the generic drug sevelamer. It is possible that some of the dosage forms included below may not apply to the brand name Renagel.

For the Consumer

Applies to sevelamer: oral capsule, oral powder for suspension, oral tablet

As well as its needed effects, sevelamer (the active ingredient contained in Renagel) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking sevelamer, check with your doctor immediately:

Incidence not known
  • Bloody, black, or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • severe constipation
  • severe vomiting
  • trouble with breathing
  • vomiting
  • vomiting of material that looks like coffee grounds, severe and continuing

Some sevelamer side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • belching
  • bloating
  • constipation
  • diarrhea
  • excess air or gas in the stomach or intestines
  • full feeling
  • passing gas
  • stomach discomfort or upset
Incidence not known
  • Itching skin
  • rash

For Healthcare Professionals

Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet


Cardiovascular side effects reported have included hypertension, hypotension, and thrombosis.[Ref]


General side effects reported included the body as a whole with complaints of headache, infection, and pain.[Ref]


Gastrointestinal side effects reported included vomiting (12% to 22%), nausea (7% to 20%), diarrhea (4% to 19%), dyspepsia (5% to 16%), abdominal pain (9%), flatulence (4% to 9%), constipation (2% to 8%) and worsening of existing constipation, and peritonitis (8%). Fecal impaction, abdominal pain, intestinal perforation, intestinal obstruction, and uncommon cases of ileus have been reported during postmarketing experience.[Ref]


Respiratory side effects reported have included increase in coughing episodes (4%).[Ref]


Metabolic side effects reported during a postmarketing study (n=18) have included decreases in bicarbonate levels not directly related to the use of sevelamer (the active ingredient contained in Renagel) but instead caused by the discontinuation of calcium salts.[Ref]


Dermatologic side effects including pruritus and rash have been reported during postmarketing experience.


1. "Product Information. Renagel (sevelamer)." Genzyme Corporation, Cambridge, MA.

2. Paz Marco MP, Muray S, Betriu A, Craver L, Belart M, Fernandez E "Treatment with sevelamer decreases bicarbonate levels in hemodialysis patients." Nephron 92 (2002): 499-500

It is possible that some side effects of Renagel may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.