Renagel Side Effects

Generic Name: sevelamer

Please note - some side effects for Renagel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Renagel - for the Consumer

Renagel

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Renagel:

Constipation; diarrhea; gas; indigestion; nausea; stomach pain; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent constipation or stomach pain.

Renagel Side Effects - for the Professional

Renagel

• The most common reasons for discontinuing treatment were gastrointestinal adverse reactions. (6.1)
• In a parallel design study, of 12 weeks duration, treatment emergent adverse reactions to Renagel Tablets in peritoneal dialysis patients included dyspepsia (12%), peritonitis (8%), diarrhea (5%), nausea (5%), constipation (4%), pruritus (4%), abdominal distension (3%), vomiting (3%), fatigue (3%), anorexia (3%), and arthralgia (3%). (6.1)
• Similar reactions at similar rates occurred in hemodialysis and peritoneal dialysis patients. (6.1)
• Cases of fecal impaction and, less commonly, ileus, bowel obstruction, and bowel perforation have been reported. (6.2)

Side Effects by Body System

Cardiovascular

Cardiovascular side effects reported have included hypertension, hypotension, and thrombosis.

General

General side effects reported included the body as a whole with complaints of headache, infection, and pain.

Gastrointestinal

Gastrointestinal side effects reported included vomiting (12% to 22%), nausea (7% to 20%), diarrhea (4% to 19%), dyspepsia (5% to 16%), abdominal pain (9%), flatulence (4% to 9%), constipation (2% to 8%) and worsening of existing constipation, and peritonitis (8%). Fecal impaction, abdominal pain, intestinal perforation, intestinal obstruction, and uncommon cases of ileus have been reported during postmarketing experience.

Respiratory

Respiratory side effects reported have included increase in coughing episodes (4%).

Metabolic

Metabolic side effects reported during a postmarketing study (n=18) have included decreases in bicarbonate levels not directly related to the use of sevelamer, but instead caused by the discontinuation of calcium salts.

Dermatologic

Dermatologic side effects including pruritis and rash have been reported during postmarketing experience.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.