Renagel Side Effects

Generic name: sevelamer

Medically reviewed by Drugs.com. Last updated on Jun 5, 2024.

Note: This document provides detailed information about Renagel Side Effects associated with sevelamer. Some dosage forms listed on this page may not apply specifically to the brand name Renagel.

Applies to sevelamer: oral powder for suspension, oral tablet.

Common side effects of Renagel

Some side effects of sevelamer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• acid or sour stomach
• belching
• excess air or gas in the stomach or intestines
• full feeling
• passing gas
• stomach discomfort or upset

Serious side effects of Renagel

Along with its needed effects, sevelamer (the active ingredient contained in Renagel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sevelamer:

Incidence not known

• bloating
• bloody, black, or tarry stools
• constipation
• diarrhea
• fast heartbeat
• fever
• heartburn
• hives, itching, rash
• hoarseness
• indigestion
• irritation
• joint pain, stiffness, or swelling
• nausea or vomiting
• redness of the skin
• stomach pain, cramping, burning, or tenderness
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• troubled breathing or swallowing
• vomiting of material that looks like coffee grounds, severe and continuing

For healthcare professionals

Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet.

General

The most frequently occurring adverse reactions included nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, and constipation.^[Ref]

Gastrointestinal

• Very common (10% or more): Vomiting (22%), nausea (20%), diarrhea (19%), dyspepsia (16%)
• Common (1% to 10%): Abdominal pain, flatulence, constipation, gastrointestinal reflux disease
• Frequency not reported: Dysphagia, diverticulitis
• Postmarketing reports: Fecal impaction, ileus, intestinal obstruction, intestinal perforation^[Ref]

Gastrointestinal events are the most common adverse reactions reported with this drug. Based on studies of 8 to 52 weeks, the most common reason for drug withdrawal are gastrointestinal adverse reactions (3% to 16%).^[Ref]

Immunologic

• Common (1% to 10%): Peritonitis^[Ref]

A clinical study in patients receiving peritoneal dialysis (n=143) found the most frequently occurring treatment emergent serious adverse reaction was peritonitis. Peritonitis occurred in 8 patients receiving sevelamer and 2 patients on active control.^[Ref]

Metabolic

• Common (1% to 10%): Anorexia
• Uncommon (0.1% to 1%): Acidosis, increased serum chloride levels, decreased carbon dioxide^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity^[Ref]

Respiratory

• Very common (10% or more): Nasopharyngitis, bronchitis
• Common (1% to 10%): Cough, upper respiratory tract infection, dyspnea^[Ref]

Dermatologic

• Postmarketing reports: Pruritus, rash^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Local

• Common (1% to 10%): Arteriovenous fistula site complication, arteriovenous fistula site hemorrhage, arteriovenous fistula thrombosis^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache^[Ref]

Other

• Common (1% to 10%): Fatigue, fever^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, muscle spasms, extremity pain^[Ref]

Further information

Renagel side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer