Ponstel Side Effects
Generic Name: mefenamic acid
Please note - some side effects for Ponstel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Ponstel - for the Consumer
Ponstel
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ponstel:
Seek medical attention right away if any of these SEVERE side effects occur when using Ponstel:Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach upset.
Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
TopPonstel Side Effects - for the Professional
Ponstel
In patients taking Ponstel or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1-10% of patients are:
Gastrointestinal experiences including - abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal), vomiting, abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes, tinnitus
Additional adverse experiences reported occasionally and listed here by body system include:
Body as a whole - fever, infection, sepsis
Cardiovascular system - congestive heart failure, hypertension, tachycardia, syncope
Digestive system - dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice
Hemic and lymphatic system - ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia
Metabolic and nutritional - weight changes
Nervous system - anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness; insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo
Respiratory system - asthma, dyspnea
Skin and appendages - alopecia, photosensitivity, pruritus, sweat
Special senses - blurred vision
Urogenital system - cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure
Other adverse reactions, which occur rarely are:
Body as a whole - anaphylactoid reactions, appetite changes, death
Cardiovascular system - arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis
Digestive system - eructation, liver failure, pancreatitis
Hemic and lymphatic system - agranulocytosis, hemolytic anemia, aplastic anemia, lymph-adenopathy, pancytopenia
Metabolic and nutritional - hyperglycemia
Nervous system - convulsions, coma, hallucinations, meningitis
Respiratory - respiratory depression, pneumonia
Skin and appendages - angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria
Special senses - conjunctivitis, hearing impairment
TopSide Effects by Body System - for Healthcare Professionals
Gastrointestinal
Gastrointestinal side effects have included abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal), and vomiting. Dry mouth, esophagitis, gastritis, glossitis, melena, rectal bleeding, and hematemesis have also been reported. Eructation, appetite changes, and pancreatitis have been reported rarely.
General
General side effects have included edema, tinnitus, fever, infection, and sepsis. Hearing loss and death have been reported rarely.
Cardiovascular
Cardiovascular side effects have included congestive heart failure, hypertension, tachycardia, and syncope. Arrhythmia, hypotension, myocardial infarction, palpitations, and vasculitis have also been reported.
Hematologic
Hematologic side effects have included anemia, increased bleeding time, ecchymosis, eosinophilia, leukopenia, purpura, and thrombocytopenia. Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, and pancytopenia have been reported rarely.
Metabolic
Metabolic side effects have included weight changes. Hyperglycemia has been reported rarely.
Nervous system
Nervous system side effects have included dizziness, headaches, asthenia, confusion, drowsiness, insomnia, malaise, somnolence, paresthesia, tremors, and vertigo. Convulsions, coma, hallucinations, and meningitis have been reported rarely.
Respiratory
Respiratory side effects have included asthma and dyspnea. Respiratory depression and pneumonia have been reported rarely.
Dermatologic
Dermatologic side effects have included pruritus, rashes, alopecia, and photosensitivity. Angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, and urticaria have been reported rarely.
Hepatic
Hepatic side effects have included elevated liver enzymes, hepatitis, and jaundice. Liver failure has been reported rarely.
Ocular
Ocular side effects have included blurred vision. Conjunctivitis has been reported rarely.
Genitourinary
Genitourinary side effects have included cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, and proteinuria.
Renal
Renal side effects have included abnormal renal function and renal failure.
Psychiatric
Psychiatric side effects have included anxiety, depression, dream abnormalities, and nervousness.
Hypersensitivity
Hypersensitivity side effects have rarely included anaphylaxis.
TopMore Ponstel resources
- Ponstel Prescribing Information (FDA)
- Ponstel MedFacts Consumer Leaflet (Wolters Kluwer)
- Ponstel Concise Consumer Information (Cerner Multum)
- Ponstel Monograph (AHFS DI)
- Ponstel Advanced Consumer (Micromedex) - Includes Dosage Information
- Mefenamic Acid Professional Patient Advice (Wolters Kluwer)
- Mefenamic Acid Prescribing Information (FDA)
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