Ponstel Side Effects

Generic Name: mefenamic acid

Note: This page contains side effects data for the generic drug mefenamic acid. It is possible that some of the dosage forms included below may not apply to the brand name Ponstel.

It is possible that some side effects of Ponstel may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to mefenamic acid: oral capsule

As well as its needed effects, mefenamic acid (the active ingredient contained in Ponstel) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking mefenamic acid, check with your doctor immediately:

More common
  • Bloody urine
  • bloody, black, or tarry stools
  • decreased frequency or amount of urine
  • heartburn
  • increased bleeding time
  • increased blood pressure
  • increased thirst
  • indigestion
  • itching skin
  • loss of appetite
  • lower back or side pain
  • nausea
  • pale skin
  • rashes
  • severe abdominal pain, cramping, or burning
  • stomach bloating
  • swelling
  • swelling of the face, fingers, feet, or lower legs
  • trouble breathing with or without exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • vomiting of material that looks like coffee grounds, severe and continuing
  • weight gain
  • weight loss
Less common
  • Bleeding gums
  • blood in vomit
  • blurred vision
  • burning feeling in the chest or stomach
  • chest pain
  • clay-colored stools
  • cloudy urine
  • confusion
  • constipation
  • cough or hoarseness
  • dark urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • difficulty in swallowing
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever or chills
  • frequent urge to urinate
  • headache
  • increased volume of pale, dilute urine
  • irregular breathing
  • irregular heartbeat
  • large, flat, blue, or purplish patches in the skin
  • light-colored stools
  • lightheadedness
  • nervousness
  • noisy breathing
  • pain or burning throat
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • rapid, slow breathing
  • redness, swelling, or soreness of tongue
  • severe or continuing stomach pain
  • shortness of breath
  • slow heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stomach upset
  • swelling or inflammation of the mouth
  • swollen glands
  • tenderness in the stomach area
  • tightness in the chest
  • tremors
  • unpleasant breath odor
  • upper right abdominal pain
  • weight changes
  • wheezing
  • yellow eyes and skin
Rare
  • Blistering, peeling, or loosening of the skin
  • change in consciousness
  • chest discomfort
  • continuing vomiting
  • cracks in the skin
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of illness
  • high fever
  • hives
  • increased hunger
  • irregular, fast or slow, or shallow breathing
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • leg pain
  • loss of consciousness
  • loss of heat from the body
  • no blood pressure
  • no breathing
  • no pulse
  • nosebleeds
  • painful glands
  • pain or discomfort in the arms, jaw, back, or neck
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • racing heartbeat or pulse
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • redness or soreness of the skin
  • scaly skin
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe headache
  • sneezing
  • sores, welting, or blisters
  • stiff neck and/or back
  • sweating
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unexplained weight loss

If any of the following symptoms of overdose occur while taking mefenamic acid, get emergency help immediately:

Symptoms of overdose
  • Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some mefenamic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • excess air or gas in the stomach or intestines
  • full feeling
  • hearing loss
  • passing gas
  • stomach discomfort
Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • discouragement
  • dry mouth
  • fear
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • hair loss, thinning of the hair
  • increased sensitivity of skin to sunlight
  • irritability
  • lack of appetite
  • lack of interest or pleasure
  • lack or loss of strength
  • redness or other discoloration of the skin
  • sensation of spinning
  • severe sunburn
  • sleepiness
  • sleeplessness
  • trouble concentrating
  • trouble sleeping
  • unable to sleep
Rare
  • Appetite changes
  • burning, dry, or itching eyes
  • change in hearing
  • discharge, excessive tearing
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to mefenamic acid: oral capsule

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal), and vomiting. Dry mouth, esophagitis, gastritis, glossitis, melena, rectal bleeding, and hematemesis have also been reported. Eructation, appetite changes, and pancreatitis have been reported rarely.

General

General side effects have included edema, tinnitus, fever, infection, and sepsis. Hearing loss and death have been reported rarely.

Cardiovascular

Cardiovascular side effects have included congestive heart failure, hypertension, tachycardia, and syncope. Arrhythmia, hypotension, myocardial infarction, palpitations, and vasculitis have also been reported.

Hematologic

Hematologic side effects have included anemia, increased bleeding time, ecchymosis, eosinophilia, leukopenia, purpura, and thrombocytopenia. Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, and pancytopenia have been reported rarely.

Metabolic

Metabolic side effects have included weight changes. Hyperglycemia has been reported rarely.

Nervous system

Nervous system side effects have included dizziness, headaches, asthenia, confusion, drowsiness, insomnia, malaise, somnolence, paresthesia, tremors, and vertigo. Convulsions, coma, hallucinations, and meningitis have been reported rarely.

Respiratory

Respiratory side effects have included asthma and dyspnea. Respiratory depression and pneumonia have been reported rarely.

Dermatologic

Dermatologic side effects have included pruritus, rashes, alopecia, and photosensitivity. Angioedema, toxic epidermal necrosis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, and urticaria have been reported rarely.

Hepatic

Hepatic side effects have included elevated liver enzymes, hepatitis, and jaundice. Liver failure has been reported rarely.

Ocular

Ocular side effects have included blurred vision. Conjunctivitis has been reported rarely.

Genitourinary

Genitourinary side effects have included cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, and proteinuria.

Renal

Renal side effects have included abnormal renal function and renal failure.

Psychiatric

Psychiatric side effects have included anxiety, depression, dream abnormalities, and nervousness.

Hypersensitivity

Hypersensitivity side effects have rarely included anaphylaxis.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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