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Pilocarpine ophthalmic Side Effects

It is possible that some side effects of pilocarpine ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pilocarpine ophthalmic: ophthalmic device, ophthalmic gel/jelly, ophthalmic solution, ophthalmic suspension

As well as its needed effects, pilocarpine ophthalmic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pilocarpine ophthalmic, check with your doctor or nurse as soon as possible:

Symptoms of too much medicine being absorbed into the body
  • Increased sweating
  • muscle tremors
  • nausea, vomiting, or diarrhea
  • troubled breathing or wheezing
  • watering of mouth
Less common or rare
  • Eye pain

Some pilocarpine ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Blurred vision or change in near or far vision
  • decrease in night vision
Less common
  • Eye irritation
  • headache or browache

For Healthcare Professionals

Applies to pilocarpine ophthalmic: compounding powder, ophthalmic gel, ophthalmic insert, ophthalmic solution


Common (1% to 10%): Accommodative change, blurred vision, eye irritation, visual impairment, eye pain
Frequency not reported: Ciliary spasm, itching, smarting/burning, sensitization of the lids and conjunctival vascular congestion, transient myopia, lens changes with chronic use, decrease in visual acuity in poor illumination, increased pupillary block, vitreous hemorrhaging, retinal detachment[Ref]


The most commonly reported side effects were accommodative change, blurred vision, eye irritation, visual impairment, and eye pain.[Ref]


Frequency not reported: Changes in blood pressure, cardiac rhythm[Ref]


Frequency not reported: Sweating, increased salivation, lacrimation[Ref]

Nervous system

Common (1% to 10%): Headache, browache
Frequency not reported: Tremor[Ref]


Frequency not reported: Bronchial spasm, pulmonary edema[Ref]


Frequency not reported: Nausea, vomiting, diarrhea[Ref]


1. "Product Information. Pilopine HS (pilocarpine ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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