Perjeta Side Effects

Generic Name: pertuzumab

Note: This page contains side effects data for the generic drug pertuzumab. It is possible that some of the dosage forms included below may not apply to the brand name Perjeta.

It is possible that some side effects of Perjeta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pertuzumab: intravenous solution

Along with its needed effects, pertuzumab (the active ingredient contained in Perjeta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pertuzumab:

More common
  • Black, tarry stools
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • fast heartbeat
  • fever
  • hives
  • hoarseness
  • itching
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • rash
  • redness of the skin
  • sore throat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Some side effects of pertuzumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • change in taste
  • cracked lips
  • decreased appetite
  • diarrhea
  • dizziness
  • dry skin
  • ear congestion
  • hair loss or thinning of the hair
  • headache
  • loosening of the fingernails
  • loss of taste
  • loss of voice
  • nasal congestion
  • nausea
  • redness or soreness around the fingernails
  • runny nose
  • sneezing
  • vomiting
  • watering of the eyes

For Healthcare Professionals

Applies to pertuzumab: intravenous solution


Cardiovascular side effects have included left ventricular dysfunction (4.4%) and congestive heart failure (1.0%).


Dermatologic side effects have included alopecia (60.9%), rash (33.7%), nail disorder (22.9%), pruritus (14%), dry skin (10.6%), and paronychia (7.1%).


Gastrointestinal side effects have included diarrhea (66.8%), nausea (42.3%), vomiting (24.1%), stomatitis (18.9%), and constipation (15.0%).


General side effects have included fatigue (37.6%), mucosal inflammation (27.8%), asthenia (26%), peripheral edema (23.1%), and pyrexia (18.1%).


Hematologic side effects have included neutropenia (52.8%), anemia (23.1%), leukopenia (18.2%), and febrile neutropenia (13.8%).


Hypersensitivity reactions have included hypersensitivity (10.1%).


Metabolic side effects have included decreased appetite (29.2%).


Musculoskeletal side effects have included myalgia (22.9%) and arthralgia (15.5%).

Nervous system

Nervous system side effects have included peripheral neuropathy (32.4%), headache (20.9%), dysgeusia (18.4%), and dizziness (12.5%).


Ocular side effects have included increased lacrimation (14.0%).


Psychiatric side effects have included insomnia (13.3%).


Respiratory side effects have included upper respiratory tract infection (16.7%), dyspnea (14.0%), nasopharyngitis (11.8%), and pleural effusion (5.2%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.