Perjeta Side Effects

Generic name: pertuzumab

Note: This document contains side effect information about pertuzumab. Some of the dosage forms listed on this page may not apply to the brand name Perjeta.

Some side effects of Perjeta may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to pertuzumab: intravenous solution

Some people receiving a pertuzumab (the active ingredient contained in Perjeta) injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel weak, tired, or nauseated, or if you have a fast heartbeat, headache, fever, chills, muscle pain, or an unusual taste in your mouth during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction while taking pertuzumab: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• fever, chills, body aches, flu symptoms;

• white patches or sores inside your mouth or on your lips;

• feeling short of breath, even with mild exertion;

• swelling, rapid weight gain; or

• anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.

Less serious side effects are more likely to occur, such as:

• nausea, diarrhea;

• tired feeling;

• dry skin, temporary hair loss;

• mild rash or itching;

• numbness or tingling in your hands or feet; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to pertuzumab: intravenous solution

Cardiovascular

Cardiovascular side effects have included left ventricular dysfunction (4.4%) and congestive heart failure (1.0%).

Dermatologic

Dermatologic side effects have included alopecia (60.9%), rash (33.7%), nail disorder (22.9%), pruritus (14%), dry skin (10.6%), and paronychia (7.1%).

Gastrointestinal

Gastrointestinal side effects have included diarrhea (66.8%), nausea (42.3%), vomiting (24.1%), stomatitis (18.9%), and constipation (15.0%).

General

General side effects have included fatigue (37.6%), mucosal inflammation (27.8%), asthenia (26%), peripheral edema (23.1%), and pyrexia (18.1%).

Hematologic

Hematologic side effects have included neutropenia (52.8%), anemia (23.1%), leukopenia (18.2%), and febrile neutropenia (13.8%).

Hypersensitivity

Hypersensitivity reactions have included hypersensitivity (10.1%).

Metabolic

Metabolic side effects have included decreased appetite (29.2%).

Musculoskeletal

Musculoskeletal side effects have included myalgia (22.9%) and arthralgia (15.5%).

Nervous system

Nervous system side effects have included peripheral neuropathy (32.4%), headache (20.9%), dysgeusia (18.4%), and dizziness (12.5%).

Ocular

Ocular side effects have included increased lacrimation (14.0%).

Psychiatric

Psychiatric side effects have included insomnia (13.3%).

Respiratory

Respiratory side effects have included upper respiratory tract infection (16.7%), dyspnea (14.0%), nasopharyngitis (11.8%), and pleural effusion (5.2%).

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