Orthovisc Side Effects
Generic Name: hyaluronan
Note: This page contains side effects data for the generic drug hyaluronan. It is possible that some of the dosage forms included below may not apply to the brand name Orthovisc.
It is possible that some side effects of Orthovisc may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to hyaluronan: injection
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking hyaluronan (the active ingredient contained in Orthovisc)
Mild bruising, heat, redness, swelling, or pain at the injection site; temporary achy feeling; temporary knee inflammation.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
For Healthcare Professionals
Applies to hyaluronan: intra-articular solution
Local side effects have included erythema, edema, pain, and other injection site reactions in 0.2% to 2.5% of patients.
Musculoskeletal side effects have included arthralgia, arthritis, arthropathy, Baker's cyst, bursitis, joint disorder, joint effusion, joint stiffness, joint swelling, pseudosepsis, localized osteoarthritis, aggravated osteoarthritis, ecchymosis, and knee arthroplasty.
Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.
In a double-blind, controlled trial involving 226 patients with knee osteoarthritis the most frequent cause of discontinuation of sodium hyaluronate therapy was worsening of knee pain (11% vs. 13% with saline).
Gastrointestinal side effects have included nausea, diarrhea, dyspepsia, and abdominal pain.
The most common side effects have included arthralgia (12.6% vs 17.2% with saline and 0.8% with arthrocentesis), back pain (6.9% vs 12.2% with saline and 4.9% with arthrocentesis), headache (12.1% vs 16.6% with saline and 17.9% with arthrocentesis).
Other side effects have included general fatigue and pain.
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