Generic Name: hyaluronan (HYE al URE oh nan)
Brand Name: Monovisc, Orthovisc, Hydase(obsolete)
What is hyaluronan?
Hyaluronan is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.
Hyaluronan is used to treat knee pain caused by osteoarthritis.
Hyaluronan is usually given after other arthritis medications have been tried without success.
Hyaluronan may also be used for purposes not listed in this medication guide.
What is the most important information I should know about hyaluronan?
You should not receive hyaluronan if you have a bleeding disorder, or if you have an infection in your knee or in the skin around your knee.
What should I discuss with my health care provider before receiving hyaluronan?
You should not use hyaluronan if you are allergic to it, or if you have:
a bleeding or blood clotting disorder such as hemophilia; or
an infection in your knee or in the skin around your knee.
It is not known whether hyaluronan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether hyaluronan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is hyaluronan given?
Hyaluronan is injected directly into your knee joint. A healthcare provider will give you this injection.
Hyaluronan is usually given once every week for 3 to 4 weeks.
Follow your doctor's dosing instructions very carefully.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your hyaluronan injection.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving hyaluronan?
For at least 48 hours after your injection: Avoid jogging, strenuous activity, or high-impact sports such as tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time.
Hyaluronan side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
signs of infection (warmth, swelling, redness) around your knee.
Common side effects may include:
joint pain or swelling; or
swelling, pain, or mild discomfort where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Hyaluronan dosing information
Usual Adult Dose for Osteoarthritis:
2 mL intraarticularly into the knee once a week for 3 to 4 weeks.
If joint effusion is present, it should be removed before injection. A new syringe should be used for the injection.
What other drugs will affect hyaluronan?
Other drugs may interact with hyaluronan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Where can I get more information?
- Your doctor or pharmacist can provide more information about hyaluronan.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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