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MZM Side Effects

Generic Name: methazolamide

Note: This page contains information about the side effects of methazolamide. Some of the dosage forms included on this document may not apply to the brand name MZM.

Not all side effects for MZM may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to methazolamide: oral tablets

Side effects include:

Paresthesia, hearing dysfunction or tinnitus, fatigue, malaise, anorexia, altered taste, nausea, vomiting, diarrhea, polyuria, drowsiness, confusion.

For Healthcare Professionals

Applies to methazolamide: compounding powder, oral tablet

Nervous system

Nervous system side effects have included paresthesias (most often a tingling in the extremities), hearing dysfunction, tinnitus, taste alteration, drowsiness, and confusion. Flaccid paralysis and convulsions have also been reported.[Ref]


Gastrointestinal side effects have included loss of appetite, nausea, vomiting, and diarrhea.[Ref]


Genitourinary side effects have included polyuria, hematuria, and glycosuria. Crystalluria and renal calculi have been reported rarely.[Ref]


Hypersensitivity reactions have included rare reports of toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Photosensitivity has been reported occasionally.[Ref]


Dermatologic side effects have included urticaria.[Ref]


Metabolic side effects have included metabolic acidosis and electrolyte disturbances.[Ref]


General side effects have included fatigue and malaise.[Ref]


Ocular side effects have included transient myopia. This can usually be resolved with a reduction in dose or discontinuation of therapy.[Ref]


Hepatic side effects have included hepatic insufficiency.[Ref]


1. "Product Information. Neptazane (methazolamide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

2. Fraunfelder FT, Meyer SM, Bagby GC Jr, Dreis MW "Hematologic reactions to carbonic anhydrase inhibitors." Am J Ophthalmol 100 (1985): 79-81

3. Gandham SB, Spaeth GL, Di Leonardo M, Costa VP "Methazolamide-induced skin eruptions." Arch Ophthalmol 111 (1993): 370-2

4. Moroi-Fetters SE, Metz EN, Chambers RB, Davidorf FH "Aplastic anemia with platelet autoantibodies in a patient after taking methazolamide." Am J Ophthalmol 110 (1990): 570-1

5. Shirato S, Kagaya F, Suzuki Y, Joukou S "Stevens-Johnson syndrome induced by methazolamide treatment." Arch Ophthalmol 115 (1997): 550-3

6. Cotter JB "Methazolamide-induced Stevens-Johnson syndrome: a warning!" Arch Ophthalmol 116 (1998): 117

7. Coudon WL, Block AJ "Acute respiratory failure precipitated by a carbonic anhydrase inhibitor." Chest 69 (1976): 112-3

8. Krivoy N, Ben-Arieh Y, Carter A, Alroy G "Methazolamide-induced hepatitis and pure RBC aplasia." Arch Intern Med 141 (1981): 1229-30

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