Multihance Side Effects

Generic name: gadobenate dimeglumine

Note: This document contains side effect information about gadobenate dimeglumine. Some of the dosage forms listed on this page may not apply to the brand name Multihance.

Some side effects of Multihance may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to gadobenate dimeglumine: intravenous solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking gadobenate dimeglumine (the active ingredient contained in Multihance) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadobenate dimeglumine may occur up to several days after injection.

Call your doctor at once if you have a serious side effect such as:

• urinating less than usual or not at all;

• drowsiness, confusion, mood changes, increased thirst, loss of appetite;

• swelling, weight gain, feeling short of breath;

• seizure (convulsions);

• breathing problems;

• pounding heartbeats or fluttering in your chest; or

• pain, burning, swelling, blistering, or skin changes where the injection was given (may occur up to several days after injection).

Less serious side effects of gadobenate dimeglumine may include:

• headache, dizziness;

• dry mouth, nausea, vomiting;

• feeling unusually hot;

• unusual or unpleasant taste in your mouth;

• numbness or tingly feeling;

• mild itching or rash; or

• cold feeling, warmth, pain, or bruising where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to gadobenate dimeglumine: intravenous solution

Cardiovascular

Cardiovascular side effects have included hypertension, vasodilatation, and tachycardia.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and diarrhea.

Hematologic

Hematologic side effects have included anemia.

Nervous system

Nervous system side effects have included headache, paresthesia, and dizziness.

Dermatologic

Dermatologic side effects have included rash.

General

General side effects have included taste perversion.

Local

Local side effects have included pain and injection site reactions.

Hypersensitivity

Hypersensitivity side effects have included anaphylactic and anaphylactoid reactions involving cardiovascular, respiratory and/or cutaneous manifestations which ranged from mild to severe. Some patients experienced circulatory collapse and died. In most cases, initial symptoms occurred within minutes of administration and resolved with prompt emergency treatment.

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