Gadobenate use while Breastfeeding

Drugs containing Gadobenate: Multihance

Gadobenate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although early investigators recommended withholding breastfeeding following administration of gadolinium contrast agents, a more recent and much larger study on another agent, gadopentetate, indicated that the amounts of gadolinium excreted into breastmilk are less than 1% of the amount allowed to be given to infants. In addition, because gadolinium contrast agents are poorly absorbed orally, none is likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium.[1][2][3] However, because there is no published experience with gadobenate during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Gadopentetate

References

1. American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2012;Version 8:79-80.

2. Webb JA, Thomsen HS, Morcos SK et al. The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005;15:1234-40. PMID: 15609057

3. Chen MM, Coakley FV, Kaimal A, Laros RK Jr. Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol. 2008;112:333-40. PMID: 18669732

Gadobenate Identification

Substance Name

Gadobenate

CAS Registry Number

113662-23-0

Drug Class

  • Contrast Media
  • Diagnostic Agents

Administrative Information

LactMed Record Number

569

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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