MultiHance Dosage

Generic name: gadobenate dimeglumine 529mg in 1mL
Dosage form: injection, solution
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com. Last updated on Aug 1, 2024.

2.1 Dosing and Imaging Instructions

MRI of the CNS

In adults and in pediatric patients over 2 years of age, the recommended dose of MultiHance for MRI of the CNS is 0.2 mL/kg (0.1 mmol/kg) administered as a rapid bolus intravenous injection. In pediatric patients below 2 years of age, the recommended dosage range is 0.1 to 0.2 mL/kg administered as a rapid bolus intravenous injection. To ensure complete injection of the contrast medium, follow the injection with a saline flush of at least 5 mL. Imaging of the CNS can be performed starting immediately after the bolus injection of MultiHance.

MRA of Renal and Aorto-ilio-femoral Vessels

For MRA examination, the recommended dose is 0.2 mL/kg (0.1 mmol/kg) administered as a rapid bolus intravenous injection followed by at least 20 mL saline flush either manually or using an automatic injector system. Start imaging immediately after the administration of MultiHance, with scan delay calculated by test bolus or automatic bolus detection technique. If an automatic contrast detection pulse sequence is not used for bolus timing, then a test bolus injection of 1-2 mL of MultiHance should be used to calculate the appropriate scan delay.

2.2 Dosing Table

*For pediatric patients less than 2 years of age, one-half of the per kg dose may be used.
TABLE 1: WEIGHT-BASED DOSING VOLUMES FOR: CNS IMAGING (ADULTS AND PEDIATRICS ≥2 YEARS OF AGE*) AND MRA IMAGING (ADULTS ONLY)
		0.1mM/kg dose
Kilograms (Kg)	Pounds (lb)	Volume, Milliliters (mL)
2.5	5.5	0.5
5	11	1.0
10	22	2.0
15	33	3.0
20	44	4.0
25	55	5.0
30	66	6.0
35	77	7.0
40	88	8.0
45	99	9.0
50	110	10.0
55	121	11.0
60	132	12.0
65	143	13.0
70	154	14.0
75	165	15.0
80	176	16.0
85	187	17.0
90	198	18.0
95	209	19.0
100	220	20.0
105	231	21.0
110	242	22.0
115	253	23.0
120	264	24.0
125	275	25.0
130	286	26.0
135	297	27.0
140	308	28.0
145	319	29.0
150	330	30.0

2.3 Administration

Inspect the MultiHance vial visually for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored or particulate matter is present. Draw MultiHance into a syringe and inject using sterile technique.

Do not mix intravenous medications or parenteral nutrition solutions with MultiHance. Do not administer other medications in the same intravenous line with MultiHance.

MultiHance vials are intended for single use only. Administer immediately after opening and discard any unused product.