Skip to Content

Mozobil Side Effects

Generic Name: plerixafor

Note: This page contains information about the side effects of plerixafor. Some of the dosage forms included on this document may not apply to the brand name Mozobil.

Not all side effects for Mozobil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to plerixafor: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by plerixafor (the active ingredient contained in Mozobil). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking plerixafor:

More common
  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts
  • increased menstrual flow or vaginal bleeding
  • irritation
  • itching skin
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • shortness of breath
  • skin rash
  • swelling
  • unusually warm skin
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness
  • wheezing

Some of the side effects that can occur with plerixafor may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bloated
  • diarrhea
  • difficulty in moving
  • excess air or gas in stomach or intestines
  • full feeling
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • vomiting
Less common
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • muscle or bone pain
  • pressure in the stomach
  • stomach discomfort, upset, or pain
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution


Gastrointestinal side effects including diarrhea (37%), nausea (34%), vomiting (10%), flatulence (7%), abdominal pain, abdominal distention, dry mouth, stomach discomfort, oral hypoesthesia, constipation, and dyspepsia have been reported.[Ref]


Local side effects including injection site reactions (34%) have been reported. Mild to moderate injection site reactions at the site of subcutaneous administration of plerixafor (the active ingredient contained in Mozobil) have included erythema, hematoma, hemorrhage, induration, inflammation, irritation, pain, paresthesia, pruritus, rash, swelling, and urticaria.[Ref]


General side effects including fatigue (27%) and malaise have been reported.[Ref]

Nervous system

Nervous system side effects including headache (22%), dizziness (11%), and vasovagal reactions have been reported.[Ref]


Musculoskeletal side effects including arthralgia (13%) and musculoskeletal pain have been reported.[Ref]


Psychiatric side effects including insomnia (7%) have been reported.[Ref]


Dermatologic side effects including hyperhidrosis and erythema have been reported.[Ref]


Respiratory side effects including a case of dyspnea and a case of hypoxia have been reported.[Ref]


Ocular side effects including periorbital swelling have been reported.[Ref]


Hematologic side effects have included hyperleukocytosis (7%).


Hypersensitivity reactions have included postmarketing reports of anaphylactic reactions, including anaphylactic shock.


1. "Product Information. Mozobil (plerixafor)." Genzyme Corporation, Cambridge, MA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.