MetroCream Side Effects

Please note - some side effects for MetroCream may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of MetroCream - for the Consumer

MetroCream Cream

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using MetroCream Cream:

Mild burning, dryness, itching, scaling, or stinging.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe burning, dryness, irritation, itching, scaling, or stinging; tingling or numbness of the hands or feet.

Side Effects by Body System

Local

Local side effects have included skin irritation, dryness, redness, burning, and stinging. At times, the local effects of metronidazole may be difficult to distinguish from the clinical characteristics of acne rosacea. Watering or tearing may occur when metronidazole is applied too close to the eyes.

Genitourinary

Genitourinary side effects including vaginal or vulvar burning, irritation, or itching have been reported following administration of intravaginal metronidazole. In approximately 6% of patients, symptomatic vaginal candidiasis occurs during or immediately after metronidazole therapy. Uterine cramping has also been reported in less than 4% of patients.

Gastrointestinal

Gastrointestinal side effects including cramps/pain (3.4%), nausea (2.0%), and metallic or bad taste (1.7%) have been reported during vaginal administration of metronidazole.

Hematologic

A 58-year-old female with possible vaginal infection experienced TTP coincident with metronidazole therapy. She presented to the hospital with chest pain and blood in her urine three days after she was administered metronidazole 0.75% vaginal gel. She was diagnosed with TTP based on her laboratory and clinical findings. Her condition resolved after treatment.

Hematological side effects have included a case of thrombotic thrombocytopenic purpura (TTP).

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