Methsuximide Side Effects

Some side effects of methsuximide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to methsuximide: oral capsule

Get emergency medical help if you have any of these signs of an allergic reaction while taking methsuximide: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

• signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), mouth sores, feeling very weak or tired;

• signs of liver damage, such as nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• joint pain or swelling with fever, swollen glands, muscle aches, chest pain;

• patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight);

• severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling; or

• worsening of seizures.

Less serious side effects of methsuximide may include:

• diarrhea, constipation;

• stomach pain, nausea, weight loss;

• dizziness, drowsiness, nervousness, confusion;

• headache;

• blurred vision; or

• loss of balance or coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to methsuximide: oral capsule

Ocular

Ocular side effects have included periorbital edema.

Genitourinary

Genitourinary side effects have included proteinuria and microscopic hematuria.

Cardiovascular

Cardiovascular side effects have included hyperemia.

Dermatologic

Dermatologic side effects have included urticaria, Stevens-Johnson syndrome, and pruritic erythematous rashes.

Nervous system

Nervous system side effects have included drowsiness, ataxia or dizziness, irritability and nervousness, headache, blurred vision, photophobia, hiccups, and insomnia.

Psychiatric

Psychiatric side effects have included confusion, instability, mental slowness, depression, hypochondriacal behavior, and aggressiveness. There have also been rare reports of psychosis, suicidal behavior, and auditory hallucinations.

Hematologic

Hematologic side effects have included eosinophilia, leukopenia, monocytosis, and pancytopenia with or without bone marrow suppression.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, anorexia, diarrhea, weight loss, epigastric and abdominal pain, and constipation.

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