Methsuximide Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Seizures

Initial dose: 300 mg orally once a day for the first week.

Maintenance dose: If required, the daily dosage may be increased at weekly intervals by 300 mg/day to a maximum of 1200 mg orally daily in 1 to 2 divided doses daily.

Because therapeutic effect and tolerance vary among patients, therapy with methsuximide must be individualized according to the response of each patient. Optimal dosage is that amount of methsuximide which is barely sufficient to control seizures so that side effects may be kept to a minimum.

Usual Pediatric Dose for Seizures

Initial dose: 150 mg orally once a day for the first week.

Target dose: If required, the daily dosage may be increased at weekly intervals by 150 mg to 300 mg/day to a maximum of 1200 mg orally daily in 1 to 2 divided doses daily.

The optimal dose is that which is just sufficient to control seizures without causing disturbing side effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Methsuximide may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a motor vehicle or other such activities requiring alertness; therefore, patients should be cautioned accordingly.

Dialysis

Data not available

Other Comments

Treatment should proceed slowly when increasing or decreasing dosage as well as when adding or eliminating other medication. Abrupt withdrawal of anticonvulsant medications may precipitate petit mal status.

The smaller capsule (150 mg) facilitates administration to small children.

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