Methsuximide Pregnancy and Breastfeeding Warnings

Methsuximide is also known as: Celontin

Methsuximide Pregnancy Warnings

Methsuximide has not been formally assigned to a pregnancy category by the FDA. Methsuximide has been assigned to pregnancy Risk Factor C by Briggs et al. Reports suggest an association between the use of anticonvulsant drugs by women with epilepsy and an elevated incidence of birth defects in children born to these women. No definite cause and effect has been proven. One source states that succinimide anticonvulsants should be considered the anticonvulsants of choice for the treatment of petit mal epilepsy during the first trimester. Methsuximide is only recommended for use during pregnancy when benefit outweighs risk.

To provide information regarding the effects of in utero exposure to methsuximide, physicians are advised to recommend that pregnant patients taking methsuximide enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This can be done by calling the toll free number 1-888-233-2334, and must be done by patients themselves. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/.

Methsuximide Breastfeeding Warnings

There are no data on the excretion of methsuximide into human milk.

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