Mechlorethamine Side Effects

Not all side effects for mechlorethamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to mechlorethamine: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by mechlorethamine. In the event that any of these side effects do occur, they may require medical attention.

Also, because of the way cancer medicines act on the body, there is a chance that they might cause other effects that may not occur until months or years after these medicines are used. These delayed effects may include certain types of cancer. Discuss these possible effects with your doctor.

You should check with your doctor immediately if any of these side effects occur when taking mechlorethamine:

Less common
  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • pain or redness at place of injection
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising
Rare
  • Shortness of breath, itching, or wheezing

If any of the following side effects occur while taking mechlorethamine, check with your doctor or nurse as soon as possible:

More common
  • Missing menstrual periods
  • painful rash
Less common
  • Dizziness
  • joint pain
  • loss of hearing
  • ringing in ears
  • swelling of feet or lower legs
Rare
  • Numbness, tingling, or burning of fingers, toes, or face
  • sores in mouth and on lips
  • yellow eyes or skin

Some of the side effects that can occur with mechlorethamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Nausea and vomiting (usually lasts only 8 to 24 hours)
Less common
  • Confusion
  • diarrhea
  • drowsiness
  • headache
  • loss of appetite
  • metallic taste
  • weakness

This medicine may cause a temporary loss of hair in some people. After treatment with mechlorethamine has ended, normal hair growth should return.

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

For Healthcare Professionals

Applies to mechlorethamine: injectable powder for injection

General

The most commonly reported side effect was hematopoietic system depression.

Hematologic

Rare (less than 0.1%): Hemolytic anemia
Frequency not reported: Lymphocytopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia, hyperheparenemia, hematopoietic system depression

Hypersensitivity

Frequency not reported: Hypersensitivity reactions, including anaphylaxis

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea, gum bleeding, gastrointestinal tract bleeding

Dermatologic

Frequency not reported: Alopecia, maculopapular skin eruption, erythema multiforme, petechiae, small subcutaneous hemorrhages

Cardiovascular

Frequency not reported: Thrombosis, thrombophlebitis

Other

Frequency not reported: Vertigo, tinnitus, diminished hearing, chromosomal abnormalities, weakness, pain

Hepatic

Frequency not reported: Jaundice

Genitourinary

Frequency not reported: Catamenia, oligomenorrhea, temporary or permanent amenorrhea, spermatogenesis, azoospermia, total germinal aplasia

Immunologic

Frequency not reported: Herpes zoster

Metabolic

Frequency not reported: Anorexia, hyperuricemia

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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