Mechlorethamine Pregnancy and Breastfeeding Warnings

Mechlorethamine is also known as: Mustargen

Mechlorethamine Pregnancy Warnings

Because gonads are susceptible to mechlorethamine, treatment may be followed by delayed catamenia, oligomenorrhea, or amenorrhea. Impaired spermatogenesis, azoospermia and total germinal aplasia have been reported in male patients treated with alkylating agents, especially in combination with other drugs. Mechlorethamine therapy in males has been observed to produce testicular germinal cell depletion and azoospermia. Patients should be warned of the potential risk to their reproductive capacity. Following first trimester mechlorethamine administration, two malformed infants have been reported. Mechlorethamine has been shown to produce fetal malformations in the rat and ferret when given as single subcutaneous injections of 1 mg/kg.

Mechlorethamine has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of fetal harm. There are no controlled data in human pregnancy. Mechlorethamine should only be given during pregnancy when there are no alternatives and benefit outweighs risk. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, she should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant while receiving this medication.

Mechlorethamine Breastfeeding Warnings

There are no data on the excretion of mechlorethamine into human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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