Mechlorethamine Pregnancy and Breastfeeding Warnings

Mechlorethamine is also known as: Mustargen

Mechlorethamine Pregnancy Warnings

Because gonads are susceptible to mechlorethamine, treatment may be followed by delayed catamenia, oligomenorrhea, or amenorrhea. Impaired spermatogenesis, azoospermia and total germinal aplasia have been reported in male patients treated with alkylating agents, especially in combination with other drugs. Mechlorethamine therapy in males has been observed to produce testicular germinal cell depletion and azoospermia. Patients should be warned of the potential risk to their reproductive capacity. Following first trimester mechlorethamine administration, two malformed infants have been reported. Mechlorethamine has been shown to produce fetal malformations in the rat and ferret when given as single subcutaneous injections of 1 mg/kg.

Mechlorethamine has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of fetal harm. There are no controlled data in human pregnancy. Mechlorethamine should only be given during pregnancy when there are no alternatives and benefit outweighs risk. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, she should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant while receiving this medication.

Mechlorethamine Breastfeeding Warnings

There are no data on the excretion of mechlorethamine into human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.