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mechlorethamine topical

Generic Name: mechlorethamine topical (MEK lor ETH a meen TOP ik al)
Brand Name: Valchlor

What is mechlorethamine topical?

Mechlorethamine topical (for the skin) is used to treat Stage 1A or 1B mycosis fungoides-type cutaneous T-cell lymphoma.

Mechlorethamine topical is usually given after other skin treatments have been tried without success.

Mechlorethamine topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about mechlorethamine topical?

Avoid getting this medication in your eyes. Mechlorethamine topical gel can cause blindness or permanent injury to your eyes. If this medication gets in your eyes, rinse them for at least 15 minutes with a large amount of water, normal saline, or an eye wash solution, and then seek emergency medical attention.

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Avoid getting this medication in your mouth or nose. If this does happen, rinse for at least 15 minutes with a large amount of water and seek emergency medical attention. Mechlorethamine topical can cause pain, redness, or ulcers if it gets in your mouth or nose.

Always get emergency medical help if this medication accidentally gets in your eyes, nose, or mouth.

What should I discuss with my healthcare provider before taking mechlorethamine topical?

You should not use this medication if you are allergic to mechlorethamine.

Mechlorethamine topical can be dangerous if it gets on the skin of another person. Caregivers should wear disposable gloves while applying this medication to the person who is affected with cutaneous T-cell lymphoma.

Using this medicine may increase your risk of developing other types of skin cancer. Your doctor will need to check your skin on a regular basis while you are using mechlorethamine topical.

FDA pregnancy category D. Do not use mechlorethamine topical if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether mechlorethamine topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I use mechlorethamine topical?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Mechlorethamine topical is usually applied once daily.

Store this medicine in its original container (box) in the refrigerator. Do not freeze. Avoid allowing this medicine to come into contact with food in the refrigerator.

Apply the medicine within 30 minutes after removing it from the refrigerator. After use, put the medicine back into the refrigerator right away.

Do not use within the first 30 minutes after taking a shower or bath. Make sure the skin is completely dry before applying the medicine. Do not bathe or shower for at least 4 hours after applying mechlorethamine topical.

Apply a thin layer of the medicine to the affected skin areas. Allow the gel to dry for 5 to 10 minutes before covering the treated skin with clothing.

Do not cover the treated skin area with a bandage.

You may apply skin lotion, cream, or oil to treated skin 2 hours before or 2 hours after applying mechlorethamine topical.

Wash your hands after applying or handling this medicine. If you are a caregiver, wear disposable gloves to apply the medicine to the patient and wash your hands after removing the gloves and throwing them away.

Mechlorethamine topical gel is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

Throw away any unused mechlorethamine topical gel after 60 days. Throw away unused gel, empty tubes, and used disposable gloves in a trash container out of the reach of children and pets.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using mechlorethamine topical?

Avoid getting this medication in your eyes. Mechlorethamine topical gel can cause blindness or permanent injury to your eyes. If this medication gets in your eyes, rinse them for at least 15 minutes with a large amount of water, normal saline, or an eye wash solution, and then call your doctor.

Avoid getting this medication in your mouth or nose. If this does happen, rinse for at least 15 minutes with a large amount of water and call your doctor. Mechlorethamine topical can cause pain, redness, or ulcers if it gets in your mouth or nose.

Always get emergency medical help if this medication accidentally gets in your eyes, nose, or mouth.

Mechlorethamine topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe skin irritation, itching, or blistering; or

  • redness or swelling, warmth, pus, oozing, or other signs of skin infection.

Common side effects may include:

  • mild skin itching or other irritation; or

  • changes in the color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Mechlorethamine topical dosing information

Usual Adult Dose for Mycosis Fungoides:

Apply a thin film once daily to affected areas of the skin.

Use: The topical treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy

What other drugs will affect mechlorethamine topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied mechlorethamine. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your pharmacist can provide more information about mechlorethamine topical.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Revision Date: 2013-10-14, 11:30:53 PM.

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