Mechlorethamine Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Malignant Disease

0.4 mg/kg IV once a month or
0.2 mg/kg IV once a day for 2 days or
0.1 mg/kg IV once a day for 4 days or
6 mg/m² IV on days 1 and 8 of a 28 day cycle, as part of the MOPP regimen for Hodgkin's disease or
0.4 mg/kg intracavity injection one time or
0.2 mg/kg intrapericardial injection one time.

Usual Adult Dose for Mycosis Fungoides

0.01% topically once a day.

Usual Pediatric Dose for Malignant Disease

Child: 0.4 mg/kg IV once a month or
0.2 mg/kg IV once a day for 2 days or
0.1 mg/kg IV once a day for 4 days or
6 mg/m² IV on days 1 and 8 of a 28 day cycle, as part of the MOPP regimen for Hodgkin's disease or
0.4 mg/kg intracavity injection one time or
0.2 mg/kg intrapericardial injection one time.

Dose Adjustments

When used as part of combination chemotherapy, doses may need to be reduced. It is often possible to give repeated courses as early as 3 weeks after treatment. Dosage recommendations for MOPP:
Leukocyte count Dose
3,000-3,999/mm³ 50% of normal dose
1,000-2,999/mm³ or 25% of normal dose
platelets 50,000-100,000/mm³
<1,000/mm³ or platelets do not administer
50,000/mm³

Precautions

Extreme caution is advised in exceeding the recommended doses. Subsequent courses should not be given until the patient has recovered from the previous course of therapy. Patients should be warned of the potential risk to their reproductive capacity.

Dialysis

Mechlorethamine is not removed by hemo- or peritoneal dialysis. A supplemental dose is not required.

Other Comments

Premedication with antiemetics and sedatives may help to control severe nausea and vomiting. Renal, hepatic and bone marrow functions should be monitored frequently.

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