Lanreotide Side Effects

Not all side effects for lanreotide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lanreotide: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by lanreotide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lanreotide:

More common
  • Abdominal or stomach fullness
  • blurred vision
  • chest pain or discomfort
  • dizziness
  • gaseous abdominal or stomach pain
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pale skin
  • pounding in the ears
  • recurrent fever
  • shortness of breath
  • slow, fast, or irregular heartbeat
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Some of the side effects that can occur with lanreotide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bloated or full feeling
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • excess air or gas in stomach or intestines
  • inflammation, itching, lumps, or pain at the injection site
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • stomach pain
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to lanreotide: subcutaneous solution

General

The most common adverse events were gastrointestinal disorders, cholelithiasis, and injection site reactions.[Ref]

Gastrointestinal

In one of the studies, diarrhea, abdominal pain, and flatulence increased as the dose increased.[Ref]

Very common (10% or more): Diarrhea (up to 65%), abdominal pain (34%), vomiting (19%), flatulence (14%), nausea (11%), loose stools
Common (1% to 10%): Constipation, flatulence, abdominal distension, abdominal discomfort, dyspepsia
Uncommon (0.1% to 1%): Pancreatitis, feces discolored
Frequency not reported: Steatorrhea[Ref]

Hepatic

Very common (10% or more): Cholelithiasis (27%), bladder sludge (20%), new cholelithiasis
Common (1% to 10%): ALT increased, AST abnormal, ALT abnormal, blood bilirubin increased, biliary dilatation
Uncommon (0.1% to 1%): AST increased, blood alkaline phosphatase increased, blood bilirubin abnormal
Frequency not reported: Cholecystitis[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (18%), hypertension (14%)
Common (1% to 10%): Sinus bradycardia
Uncommon (0.1% to 1%): Other cardiac adverse drug reactions[Ref]

Local

Very common (10% or more): Application site disorder (injection site mass/pain/reaction/inflammation/ nodule/pruritus, 30%)
Postmarketing reports: Persisting induration[Ref]

Metabolic

Very common (10% or more): Dysglycemia (hypoglycemia, hyperglycemia, diabetes, 14%), weight decrease (11%)
Common (1% to 10%): Blood glucose increased, glycosylated hemoglobin increased
Uncommon (0.1% to 1%): Blood sodium decreased, diabetes mellitus aggravated[Ref]

Hematologic

Very common (10% or more): Anemia (14%)[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (19%), arthralgia (11%)[Ref]

Nervous system

Very common (10% or more): Headache (16%)
Common (1% to 10%): Dizziness
Postmarketing reports: Dysautonomia[Ref]

Respiratory

Common (1% to 10%): Dyspnea[Ref]

Psychiatric

Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Insomnia[Ref]

Other

Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Hot flush, asthenia
Postmarketing reports: Malaise[Ref]

Immunologic

Common (1% to 10%): Anti-lanreotide antibodies[Ref]

Hypersensitivity

Frequency not reported: Allergic reactions (including angioedema, anaphylaxis, and hypersensitivity)[Ref]

Dermatologic

Common (1% to 10%): Alopecia, hypotrichosis[Ref]

Endocrine

Rare (less than 0.1%): Clinical hypothyroidism
Frequency not reported: Slight decreases in thyroid function[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Somatuline Depot (lanreotide)." Tercica Inc, Brisbane, CA.

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