Lanreotide Side Effects

It is possible that some side effects of lanreotide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to lanreotide: subcutaneous solution

Along with its needed effects, lanreotide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanreotide:

More common
  • Abdominal fullness
  • blurred vision
  • chest pain or discomfort
  • dizziness
  • gaseous abdominal pain
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pale skin
  • pounding in the ears
  • recurrent fever
  • shortness of breath
  • slow, fast, or irregular heartbeat
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects of lanreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloated, full feeling
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • excess air or gas in stomach or intestines
  • inflammation, itching, lumps, or pain at the injection site
  • muscle pain or stiffness
  • nausea
  • pain in joints
  • passing gas
  • stomach pain
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to lanreotide: subcutaneous solution


One percent of acromegalic patients treated with lanreotide in the pooled clinical studies discontinued treatment because of gastrointestinal reactions.

New cholelithiasis was reported in 12.0% of patients. Cholelithiasis may be related to dose or duration of exposure.

Gastrointestinal side effects including diarrhea (37%), abdominal pain (19%), nausea (11%), constipation (8%), flatulence (7%), vomiting (7%), and loose stools (6%) have been reported (percentages are from overall pooled data). A lethal case of acute necrotizing pancreatitis has also been reported. Postmarketing gastrointestinal side effects including abdominal pain, diarrhea, pancreatitis, and steatorrhea have been reported.


Hepatic side effects including cholelithiasis (20%) and gallbladder sludge (20%), have been reported. Postmarketing hepatic side effects including cholecystitis have been reported.


Local side effects injection site pain (4.1%), injection site mass (1.7%), induration, nodule, and pruritus have been reported. Postmarketing local side effects including injection site reactions have been reported.

Injection site adverse reactions were more commonly reported soon after the start of treatment and were less commonly reported as treatment continued. Such adverse reactions were usually mild or moderate but lead to withdrawal from clinical studies in two subjects.


Musculoskeletal side effects including arthralgia (7%) have been reported. (Percentage is from overall pooled data.)

Nervous system

Nervous system side effects including headache (7%) have been reported. (Percentage is from overall pooled data.)


In patients without underlying cardiac disease, lanreotide may lead to a decrease in heart rate without necessarily reaching the threshold of bradycardia. In patients suffering from cardiac disorders prior to lanreotide treatment, sinus bradycardia may occur. Care should be taken when initiating treatment with lanreotide in patients with bradycardia.

Cardiovascular side effects including hypertension (5%) and sinus bradycardia (3%) have been reported. (Percentage is from overall pooled data.)


Hematologic side effects including anemia (3%) have been reported. (Percentage is from overall pooled data.)


Metabolic side effects including dysglycemia have been reported. In clinical studies of acromegalic patients treated with lanreotide, adverse reactions of dysglycemia (hypoglycemia, hyperglycemia, diabetes) were reported by 14% of patients and were considered related to study drug in 7% of patients.

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