Hemabate Side Effects

Generic Name: carboprost

Note: This document contains side effect information about carboprost. Some of the dosage forms listed on this page may not apply to the brand name Hemabate.

Some side effects of Hemabate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to carboprost: intramuscular solution

Along with its needed effects, carboprost (the active ingredient contained in Hemabate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking carboprost:

Less common or rare
  • Fast or slow heartbeat
  • headache (severe and continuing)
  • hives or skin rash
  • increased pain of the uterus
  • pale, cool, blotchy skin on arms or legs
  • pressing or painful feeling in chest
  • shortness of breath
  • swelling of face, inside the nose, and eyelids
  • tightness in chest
  • trouble in breathing
  • weak or absent pulse in arms or legs
  • wheezing

Check with your doctor as soon as possible if any of the following side effects occur while taking carboprost:

  • Constipation
  • pain or inflammation at place of injection
  • tender or mildly bloated abdomen or stomach

Some side effects of carboprost may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • nausea
  • vomiting
Less common or rare
  • Chills or shivering
  • dizziness
  • fever (temporary)
  • flushing or redness of face
  • headache
  • stomach cramps or pain

This procedure may result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if you notice any of the following:

  • Chills or shivering (continuing)
  • fever (continuing)
  • foul-smelling vaginal discharge
  • increase in uterus bleeding
  • pain in lower abdomen

For Healthcare Professionals

Applies to carboprost: injectable solution


Pretreatment or concurrent administration of antiemetic and antidiarrheal drugs considerably decreases the very high incidence of gastrointestinal side effects that are common with all prostaglandins used for abortion.

Gastrointestinal side effects including vomiting and diarrhea (67%), nausea (33%), dryness of mouth, hematemesis, taste alterations, epigastric pain, gagging, retching, sensation of choking, dry throat, and fullness of throat have been reported.


Dermatologic side effects including hot flashes (7%), paresthesia, diaphoresis, and rash have been reported.


The degree of hypertension was moderate and it is not certain as to whether it was due to a direct effect of carboprost (the active ingredient contained in Hemabate) or a return to a status of pregnancy associated hypertension manifested by the correction of hypovolemic shock.

Cardiovascular side effects have been reported including an increase in blood pressure (4%) in the postpartum hemorrhage series of clinical studies. Hypertension, tachycardia, and palpitations have also been reported.


Genitourinary side effects including endometritis, dysmenorrhea-like pain, breast tenderness, vasovagal syndrome, urinary tract infection, posterior cervical perforation, perforated uterus, retained placental fragment, uterine sacculation, excessive uterine bleeding, and uterine rupture have been reported.

When carboprost was used for abortion, the most common complications which required additional treatment after discharge from the hospital were endometritis, retained placental fragments, and excessive uterine bleeding which was reported to have occurred in approximately 2% of patients.


General side effects have been reported including transient pyrexia, chills, shivering, drowsiness, septic shock, lethargy, sleep disorders, weakness, dizziness, excessive thirst, syncope, chest pain, faintness, and lightheadedness.

Transient pyrexia may be due to the effect of carboprost on hypothalamic thermoregulation. Temperature elevation exceeding 2 degrees Fahrenheit have been reported in approximately 12.5% of the patients who received the recommended dosage regimen. In all cases, temperature returned to normal when therapy ended.


Respiratory side effects including hiccough, coughing, asthma, hyperventilation, respiratory distress, pulmonary edema, nosebleed, dyspnea, tightness in chest, wheezing, upper respiratory infection, and shortness of breath have been reported.

Nervous system

Nervous system side effects including headaches have been reported.


Musculoskeletal side effects including backache, dystonia, muscular pain, torticollis, and leg cramps have been reported.


Ocular side effects including eye pain, blurred vision, and twitching eyelids have been reported.


Local side effects including injection site pain have been reported.


Other side effects including tinnitus and vertigo have been reported.


Psychiatric side effects including nervousness and anxiety have been reported.


Endocrine side effects including thyroid storm have been reported.


Hypersensitivity side effects have been reported postmarketing including anaphylactic reaction, anaphylactic shock, anaphylactoid reaction and angioedema.

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