First Progesterone MC5 Side Effects
Generic Name: progesterone
Note: This document contains side effect information about progesterone. Some of the dosage forms listed on this page may not apply to the brand name First Progesterone MC5.
Some side effects of First Progesterone MC5 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to progesterone: oral capsule, oral capsule liquid filled
Along with its needed effects, progesterone (the active ingredient contained in First Progesterone MC5) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking progesterone:More common
- Chest pain
- cold or flu-like symptoms
- cough or hoarseness
- problems with urination
- Clear or bloody discharge from the nipple
- dimpling of the breast skin
- inverted nipple
- lump in the breast or under the arm
- persistent crusting or scaling of the nipple
- redness or swelling of the breast
- sore on the skin of the breast that does not heal
- Abdominal or stomach pain
- blurred vision
- change in vaginal discharge
- clay-colored stools
- cleft lip or palate
- darkened urine
- difficult or labored breathing
- difficulty with swallowing
- difficulty with walking
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- irregular heartbeat
- joint pain, stiffness, or swelling
- loss of appetite
- noisy breathing
- numbness or tingling in the face, arms, or legs
- pain or feeling of pressure in the pelvis
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the skin
- shortness of breath
- slow heartbeat
- spontaneous abortion
- stomach or pelvic discomfort, aching, or heaviness
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- trouble speaking, thinking, or walking
- unpleasant breath odor
- unusual tiredness or weakness
- vaginal bleeding
- vomiting of blood
- yellow eyes or skin
Some side effects of progesterone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Breast pain or tenderness
- muscle or joint pain
- white or brownish vaginal discharge
- Attack, assault, or force
- blurred or loss of vision
- change in walking and balance
- changes in behavior
- changes in patterns and rhythms of speech
- clumsiness or unsteadiness
- confusion about identity, place, and time
- continuing ringing or buzzing or other unexplained noise in the ears
- decreased awareness or responsiveness
- difficulty with moving
- disturbed color perception
- double vision
- extreme dizziness or drowsiness
- feeling drunk
- feeling of constant movement of self or surroundings
- feeling of unreality
- hair loss or thinning of the hair
- halos around lights
- hearing loss
- hives or welts
- longer or heavier menstrual periods
- loss of consciousness
- muscle cramps
- muscle stiffness
- night blindness
- normal menstrual bleeding occurring earlier, possibly lasting longer than expected
- overbright appearance of lights
- redness of the skin
- relaxed and calm
- sensation of spinning
- sense of detachment from self or body
- severe sleepiness
- slurred speech
- swollen tongue
- thoughts of killing oneself
- tunnel vision
- weight changes
For Healthcare Professionals
Applies to progesterone: compounding powder, intramuscular solution, oral capsule, topical cream, vaginal gel, vaginal insert, vaginal suppository
Genitourinary side effects have included breast tenderness (27%), urinary problems (11%), vaginal discharge (10%), vaginal dryness (6%), breast pain (6%), breast carcinoma (2%), breast excisional biopsy (2%), breast enlargement, leukorrhea, uterine fibroid, vaginal dryness, fungal vaginitis, vaginitis, dysuria, cystitis, and urinary tract infection
Nervous system side effects have included headache (31%), dizziness (15%), confusion, somnolence, asthenia, increased sweating, nervousness, migraine, tremor, and speech disorder. Syncope (with and without hypotension) have been reported.
Cardiovascular side effects have included chest pain (7%), hypertension, angina pectoris, syncope, and palpitations.
Gastrointestinal side effects have included abdominal pain (20%), bloating (8%), diarrhea (8%), nausea (8%), constipation (3%), dyspepsia, dry mouth, gastroenteritis, hemorrhagic rectum, hiatus hernia, and vomiting. The side effects reported during clinical studies evaluating the use of progesterone (the active ingredient contained in First Progesterone MC5) gel 8% have included constipation (27%), nausea (22%), and diarrhea (8%).
Musculoskeletal side effects have included joint pain (20%), musculoskeletal pain (12%), back pain (8%), arthritis, leg cramps, hypertonia, muscle disorder, and myalgia.
Psychiatric side effects have included depression (19%), anxiety, impaired concentration, insomnia, forgetfulness, and personality disorder.
Respiratory side effects have included cough (8%), bronchitis, nasal congestion, pharyngitis, pneumonitis, and sinusitis.
Dermatologic side effects have included acne, pruritus, rash, skin discoloration, seborrhea, verruca, and wound debridement during therapy.
Additional dermatologic side effects have included case reports of familial autoimmune dermatitis.
Ocular side effects have included abnormal vision.
Hepatic side effects including reversible cases of hepatitis, elevated transaminases, and cholecystectomy have been reported.
Other side effects have included viral infection (12%), hot flashes (11%), fatigue (8%), irritability (8%), worry (8%), night sweats (7%), earache, tooth disorder, anorexia, increased appetite, peripheral edema, edema, accidental injury, fever, abscess, lymphadenopathy, and herpes simplex.
Immunologic side effects have included autoimmune dermatitis during the luteal phase of the menstrual cycle. Test results using interferon gamma release in vivo and vitro tests confirmed the diagnosis.
Local side effects have included pain, irritation, and redness at the injection site.
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